师资队伍

黄明东

姓名:黄明东

性别:男

职称:教授

学历:博士

电话:0591-22867253

电子邮件:HMD_lab@fzu.edu.cn

研究方向:结构生物学,化学生物学

教育工作经历:

教育经历(按时间倒排序):

1989/1   - 1993/3,美国俄勒冈州立大学,博士

1982/9   - 1985/7,厦门大学,物理化学,硕士

1978/9   - 1982/7,福州大学,物理化学,学士

工作经历(科研与学术工作经历,按时间倒序排序):

2016/05至今,  福州大学,教授

1999/09-2015/06,哈佛医学院贝思以色列研究中心结构生物学实验室,主任

2003/07-2016.01,中科院福建物构所化学生物学研究室,研究室主任

1993/03-1999/07,美国斯奎伯斯研究所,分子生物学系,博士后

1985/09-1988/12,中科院福建物构所,助研

教学简介:

在哈佛医学院工作期间,培养博士后6名。

回国后,在中科院福建物构所工作期间成功申报“生物化学和分子生物学”博士点(2005年),并作为学科带头人负责该博士点11年。

培养硕博士研究生29名,已毕业博士13名,硕士8名。12名博士到国外进修博士后,其中四人已经回国在国内高校担任教授。4名硕士到国外继续深造博士学位。多年来与国外单位开展研究生联合培养,中国丹麦联合培养硕博士,已有一人获得丹麦博士学位,一人获得了丹麦的Danida奖金,目前还有两人获得丹麦奖学金在攻读丹麦博士学位,同时开展中法博士联合培养,已毕业2人。

科研简介:

   黄明东教授先后主持了多项研究课题,包括中国科学院“百人计划”、   国家杰出青年基金、国家基金委重点项目、国家基金委重大国际合作项目、国家基金委面上项目、科技部863、福建省基金委重点项目等。迄今为止,共在国内外期刊发表论文140余篇,有五篇发表在《科学》和《自然》及子刊杂志上,其中三篇为第一或通讯作者,主编和参编著作3部。

两个主要研究方向:

1. 发展了一种抗菌的药物,主要特点是广谱性:可以杀灭包括革兰氏阳性和阴性的多种细菌,特别是能够杀灭耐药菌。该项技术目前已经转让给青岛阳光动力公司,并发展出抗菌PM2.5口罩等已经上市产品,并正在开发新一代产品。

2. 在药物结构生物学方向,在国际学术杂志上发表了一系列的高水平研究论文和综述,在水解酶及其调控蛋白、受体蛋白领域,特别是尿激酶和尿激酶受体的结构和功能研究方面处于世界一流行列:获得了国家基金委重大国际合作和科技部863等国家级项目的资助,也获得国外机构如澳大利亚国家健康与医学研究理事会(NHMRC)的资助,此外,还获得了制药公司的资助,包括了美国辉瑞制药、中科院诺和诺德中心、和浙江海正制药。基于这些结果组建了中国丹麦肿瘤和水解酶联合研究中心,这是中国丹麦第一个双边研究中心。

  基于结构研究发展了系列尿激酶、尿激酶受体、PAI-1的抑制剂,用于抗肿瘤、溶血栓、促纤溶等应用。

社会兼职:

中国晶体学会第三、第四届理事会理事

《结构化学》杂志编委

Nature Structural and Molecular Biology,PNAS,Blood等期刊通讯审稿人

中国光学学会第二届生物医学光子学专业委员会常委

中国生物医学工程学会生物医学光子学分会常委

中国化学会应用化学学科卟啉-酞菁专业委员会委员

福建省生物工程协会副主席

福建省化学生物学重点实验室学术委员会委员

福建省药物新靶点研究重点实验室学术委员会委员

国家自然科学基金委员会第十一和十二届生命科学部专家评审组成员

科研项目:

1.澳大利亚国家健康与医学研究理事会(NHMRC), 项目起止时间:2016.01-2020.12,批准号:APP1100432,Wollongong University,共同申请人,在研

2.国家自然科学基金面上项目,31670739,GPI-LU亚家族蛋白的结构研究,2017.01-2020.12,在研,主持

3.国家自然科学基金面上项目,31370737,纤溶酶原激活物抑制因子及其新型抑制剂的结构研究,2014.01-2017.12,在研,主持

4.国家自然科学基金面上项目,21171167,顺铂与人血清白蛋白相互作用的晶体学研究,2012.01-2015.12,已结题,主持

5.国家自然科学基金重大国际合作项目,31161130356,蛋白水解酶系统作为癌症标记和癌症治疗的靶标,2012.01-2014.12,已结题,主持

6.国家自然科学基金重大国际合作项目,30811130467,蛋白水解酶系统作为癌症标记和癌症治疗的靶标,2008.01-2011.08,已结题,主持

7.国家自然科学基金杰出青年项目,30625011,细胞膜受体及其与配体相互作用的结构研究,2007.1-2010.12,已结题,主持

8.中华人民共和国科学技术部973项目,2007CB914304,具有重大意义的蛋白质及其复合物的三维结构和功能研究,2007.1.1-2012.12.31,已结题,子课题负责人

9.中华人民共和国科学技术部863项目,2006AA02A313,癌症相关蛋白质的三维结构研究,2006.11.1-2011.11.1,已结题,主持

10.诺和诺德-中科院专项研究经费,项目起止时间:2012.01-2013.12,批准号:NNCAS-2012-5(A),已结题,主持

11.中法蔡元培交流项目,项目起止时间:2011.05-2013.05,批准号:【2011】6019,已结题,主持

12.福建省科技重点项目,项目起止时间:2010.3-2012.3,批准号:2010Y0057,已结题,主持

13.辉瑞公司横向合作项目,项目起止时间:2009.11-2011.12,已结题,主持

14.浙江海正药业股份有限公司委托项目,项目起止时间:2008.12-2009.12,已结题,主持

15.苏州技术研究院委托项目,项目起止时间:2008.05-2009.12,已结题,主持

16.中科院创新基地重要方向项目,项目起止时间:2007.01-2010.12,批准号:C01050402,已结题,主持

17.国家自然科学基金重点项目,30430190,尿激酶受体与其配体相互作用的结构基础,2005.1-2008.12,已结题,主持

代表性论文:

1.       Yaxin   Zhang, Ke Zheng, Zhuo Chen, Jincan Chen, Ping Hu, Linrong Cai, Zafar Iqbal,   and Mingdong Huang*, Rapid Killing   of Bacteria by a New Type of Photosensitizer, Applied microbiology and   biotechnology, 2017,

2.       Xiaolei   Zhou, Mingming Xu, Hailong Huang, Andrew Mazar, Zafar Lqbal, Cai Yuan, and Mingdong Huang*, An Elisa Method   Detecting the Active Form of Supar, Talanta, 2016, 160: 205-10

3.       Cai   Yuan, Henrik J. Jurgensen, Lars H. Engelholm, Rui Li, Min Liu, Longguang   Jiang, Zhipu Luo, Niels Behrendt, and Mingdong   Huang*, Crystal Structures of the Ligand-Binding Region of Uparap: Effect   of Calcium Ion Binding, Biochemical Journal, 2016, 473: 2359-68

4.       Longguang   Jiang, Lin Lin, Rui Li, Cai Yuan, Mingming Xu, Joy H. Huang, and Mingdong Huang*, Dimer Conformation   of Soluble Pecam-1, an Endothelial Marker, International Journal of   Biochemistry & Cell Biology,   2016, 77: 102-08

5.       Longguang   Jiang, Lisbeth Moreau Andersen, Peter A. Andreasen, Liqing Chen, and Mingdong Huang*, Insights into the   Serine Protease Mechanism Based on Structural Observations of the Conversion   of a Peptidyl Serine Protease Inhibitor to a Substrate, Biochimica Et   Biophysica Acta-General Subjects,   2016, 1860(3): 599-606

6.       Lihu   Gong, Valerie Proulle, Chao Fang, Zebin Hong, Zhonghui Lin, Min Liu, Guangpu   Xue, Cai Yuan, Lin Lin, Barbara Furie, Robert Flaumenhaft, Peter Andreasen,   Bruce Furie, and Mingdong Huang*,   A Specific Plasminogen Activator Inhibitor-1 Antagonist Derived from   Inactivated Urokinase, Journal of Cellular and Molecular Medicine, 2016, 20(10): 1851-60

7.       Lihu   Gong, Min Liu, Tu Zeng, Xiaoli Shi, Cai Yuan, Peter A. Andreasen, and Mingdong Huang*, Structural Basis of   Specific Inhibition of Tissue-Type Plasminogen Activator by Plasminogen   Activators Inhibitor-1, Data in brief,   2016, 6: 550-5

8.       Zhuo   Chen, Yaxin Zhang, Dong Wang, Linsen Li, Shanyong Zhou, Joy H. Huang, Jincan   Chen, Ping Hu, and Mingdong Huang*,   Photodynamic Antimicrobial Chemotherapy Using Zinc Phthalocyanine Derivatives   in Treatment of Bacterial Skin Infection, Journal of Biomedical Optics, 2016, 21(1)

9.       Xiaolei   Zhou, Ke Zheng, Rui Li, Zhuo Chen, Cai Yuan, Ping Hu, Jincan Chen, Jinping   Xue, and Mingdong Huang*, A Drug   Carrier Targeting Murine Upar for Photodynamic Therapy and Tumor Imaging,   Acta Biomaterialia, 2015, 23:   116-26

10.     Ke   Zheng, Rui Li, Xiaolei Zhou, Ping Hu, Yaxin Zhang, Yunmei Huang, Zhuo Chen,   and Mingdong Huang*, Dual Actions   of Albumin Packaging and Tumor Targeting Enhance the Antitumor Efficacy and   Reduce the Cardiotoxicity of Doxorubicin in Vivo, International Journal of   Nanomedicine, 2015, 10: 5327-42

11.     Baoyu   Zhao, Sonu Gandhi, Cal Yuan, Zhipu Luo, Rui Li, Henrik Gardsvoll, Valentina   de Lorenzi, Nicolai Sidenius, Mingdong   Huang*, and Michael Ploug*, Stabilizing a Flexible Interdomain Hinge   Region Harboring the Smb Binding Site Drives Upar into Its Closed   Conformation, Journal of Molecular Biology,   2015, 427(6): 1389-403

12.     Yu   Wang, Shihua Wang, and Mingdong Huang*,   Structure and Enzymatic Activities of Human Serum Albumin, Current   Pharmaceutical Design, 2015,   21(14): 1831-36

13.     Longguang   Jiang, Baoyu Zhao, Peng Xu, Hans Peter Sorensen, Jan K. Jensen, Anni   Christensen, Masood Hosseini, Niels Christian Nielsen, Knud J. Jensen, Peter   A. Andreasen, and Mingdong Huang*,   Distinctive Binding Modes and Inhibitory Mechanisms of Two Peptidic   Inhibitors of Urokinase-Type Plasminogen Activator with Isomeric P1 Residues,   International Journal of Biochemistry & Cell Biology, 2015, 62: 88-92

14.     Zafar   Iqbal, Jincan Chen, Zhuo Chen, and Mingdong   Huang*, Phthalocyanine-Biomolecule Conjugated Photosensitizers for   Targeted Photodynamic Therapy and Imaging, Current Drug Metabolism, 2015, 16(9): 816-32

15.     Lihu   Gong, Min Liu, Tu Zeng, Xiaoli Shi, Cai Yuan, Peter A. Andreasen, and Mingdong Huang*, Crystal Structure of   the Michaelis Complex between Tissue-Type Plasminogen Activator and   Plasminogen Activators Inhibitor-1, Journal of Biological Chemistry, 2015, 290(43): 25795-804

16.     Shanyong   Zhou, Wei Zheng, Zhuo Chen, Datao Tu, Yongsheng Liu, En Ma, Renfu Li, Haomiao   Zhu, Mingdong Huang*, and Xueyuan   Chen*, Dissolution-Enhanced Luminescent Bioassay Based on Inorganic   Lanthanide Nanoparticles, Angewandte Chemie-International Edition, 2014, 53(46): 12498-502

17.     Baoyu   Zhao, Peng Xu, Longguang Jiang, Berit Paaske, Tobias Kromann-Hansen, Jan K.   Jensen, Hans Peter Sorensen, Zhuo Liu, Jakob T. Nielsen, Anni Christensen,   Masood Hosseini, Kasper K. Sorensen, Niels Christian Nielsen, Knud J. Jensen,   Mingdong Huang*, and Peter A.   Andreasen*, A Cyclic Peptidic Serine Protease Inhibitor: Increasing Affinity   by Increasing Peptide Flexibility, Plos One, 2014, 9(12)

18.     Xiang   Xu, Yuan Cai, Ying Wei, Fernando Donate, Jose Juarez, Graham Parry, Liqing   Chen, Edward J. Meehan, Richard W. Ahn, Andrey Ugolkov, Oleksii Dubrovskyi,   Thomas V. O'Halloran, Mingdong Huang*,   and Andrew P. Mazar*, Identification of a New Epitope in Upar as a Target for   the Cancer Therapeutic Monoclonal Antibody Atn-658, a Structural Homolog of   the Upar Binding Integrin Cd11b (Alpha M), Plos One, 2014, 9(1)

19.     Rui   Li, Ke Zheng, Ping Hu, Zhuo Chen, Shanyong Zhou, Jincan Chen, Cai Yuan, Song   Chen, Wei Zheng, En Ma, Fengling Zhang, Jinping Xue, Xueyuan Chen, and Mingdong Huang*, A Novel Tumor   Targeting Drug Carrier for Optical Imaging and Therapy, Theranostics, 2014, 4(6): 642-59

20.     Zhuo   Chen, Shanyong Zhou, Jincan Chen, Linsen Li, Ping Hu, Song Chen, and Mingdong Huang*, An Effective Zinc   Phthalocyanine Derivative for Photodynamic Antimicrobial Chemotherapy,   Journal of Luminescence, 2014, 152:   103-07

21.     Zhuo   Chen, Peng Xu, Jincan Chen, Hongwei Chen, Ping Hu, Xueyuan Chen, Lin Lin,   Yunmei Huang, Ke Zheng, Shanyong Zhou, Rui Li, Song Chen, Jianyong Liu,   Jinping Xue, and Mingdong Huang*,   Zinc Phthalocyanine Conjugated with the Amino-Terminal Fragment of Urokinase   for Tumor-Targeting Photodynamic Therapy, Acta Biomaterialia, 2014, 10(10): 4257-68

22.     Baoyu   Zhao, Cai Yuan, Rui Li, Dan Qu, Mingdong   Huang*, and Jacky Chi Ki Ngo*, Crystal Structures of Matriptase in   Complex with Its Inhibitor Hepatocyte Growth Factor Activator Inhibitor-1,   Journal of Biological Chemistry,   2013, 288(16): 11155-64

23.     Yu   Wang, Haiyang Yu, Xiaoli Shi, Zhipu Luo, Donghai Lin, and Mingdong Huang*, Structural Mechanism   of Ring-Opening Reaction of Glucose by Human Serum Albumin, Journal of   Biological Chemistry, 2013,   288(22): 15980-87

24.     Zhonghui   Lin, Jan K. Jensen, Zebin Hong, Xiaoli Shi, Lihong Hu, Peter A. Andreasen,   and Mingdong Huang*, Structural   Insight into Inactivation of Plasminogen Activator Inhibitor-1 by a Small-Molecule   Antagonist, Chemistry & Biology,   2013, 20(2): 253-61

25.     Longguang   Jiang, Kenneth A. Botkjaer, Lisbeth M. Andersen, Cai Yuan, Peter A.   Andreasen, and Mingdong Huang*,   Rezymogenation of Active Urokinase Induced by an Inhibitory Antibody,   Biochemical Journal, 2013, 449:   161-66

26.     Xiang   Xu, Henrik Gardsvoll, Cai Yuan, Lin Lin, Michael Ploug, and Mingdong Huang*, Crystal Structure of   the Urokinase Receptor in a Ligand-Free Form, Journal of Molecular Biology, 2012, 416(5): 629-41

27.     Peng   Xu, Jincan Chen, Zhuo Chen, Shanyong Zhou, Ping Hu, Xueyuan Chen, and Mingdong Huang*, Receptor-Targeting   Phthalocyanine Photosensitizer for Improving Antitumor Photocytotoxicity,   Plos One, 2012, 7(5)

28.     Zhipu   Luo, Xiaoli Shi, Qin Hu, Bin Zhao, and Mingdong   Huang*, Structural Evidence of Perfluorooctane Sulfonate Transport by   Human Serum Albumin, Chemical Research in Toxicology, 2012, 25(5): 990-92

29.     Zhonghui   Lin, Longguang Jiang, Cai Yuan, Jan K. Jensen, Xu Zhang, Zhipu Luo, Barbara   C. Furie, Bruce Furie, Peter A. Andreasen, and Mingdong Huang*, Structural Basis for Recognition of   Urokinase-Type Plasminogen Activator by Plasminogen Activator Inhibitor-1,   Journal of Biological Chemistry,   2011, 286(9): 7027-32

30.     Longguang   Jiang, Anna S. P. Svane, Hans Peter Sorensen, Jan K. Jensen, Masood Hosseini,   Zhuo Chen, Caroline Weydert, Jakob T. Nielsen, Anni Christensen, Cai Yuan,   Knud J. Jensen, Niels Chr Nielsen, Anders Malmendal, Mingdong Huang*, and Peter A. Andreasen, The Binding Mechanism of   a Peptidic Cyclic Serine Protease Inhibitor, Journal of Molecular Biology, 2011, 412(2): 235-50

31.     Jincan   Chen, Zhuo Chen, Yuqian Zheng, Shanyong Zhou, Jundong Wang, Naisheng Chen,   Jinling Huang, Fuhua Yan, and Mingdong   Huang*, Substituted Zinc Phthalocyanine as an Antimicrobial Photosensitizer   for Periodontitis Treatment, Journal of Porphyrins and Phthalocyanines, 2011, 15(4): 293-99

32.     Zhuo   Liu, Lin Lin, Cai Yuan, Gerry A. F. Nicolaes, Liqing Chen, Edward J. Meehan,   Bruce Furie, Barbara Furie, and Mingdong   Huang*, Trp(2313)-His(2315) of Factor Viii C2 Domain Is Involved in   Membrane Binding Structure of a Complex between the C2 Domain and an   Inhibitor of Membrane Binding, Journal of Biological Chemistry, 2010, 285(12): 8824-29

33.     Lin   Lin, Henrik Gardsvoll, Qing Huai, Mingdong   Huang*, and Michael Ploug*, Structure-Based Engineering of Species   Selectivity in the Interaction between Urokinase and Its Receptor Implication   for Preclinical Cancer Therapy, Journal of Biological Chemistry, 2010, 285(14): 10982-92

34.     Zhuo   Chen, Shanyong Zhou, Jincan Chen, Yicai Deng, Zhipu Luo, Hongwei Chen,   Michael R. Hamblin, and Mingdong Huang*,   Pentalysine Beta-Carbonylphthalocyanine Zinc: An Effective Tumor-Targeting   Photosensitizer for Photodynamic Therapy, Chemmedchem, 2010, 5(6): 890-98

35.     Shihui   Guo, Xiaoli Shi, Feng Yang, Liqing Chen, Edward J. Meehan, Chuanbing Bian,   and Mingdong Huang*, Structural   Basis of Transport of Lysophospholipids by Human Serum Albumin, Biochemical   Journal, 2009, 423: 23-30

36.     Zhuo   Chen, Lin Lin, Qing Huai, and Mingdong   Huang*, Challenges for Drug Discovery - a Case Study of Urokinase   Receptor Inhibition, Combinatorial Chemistry & High Throughput Screening, 2009, 12(10): 961-67

37.     Lili   Zhu, Feng Yang, Liqing Chen, Edward J. Meehan, and Mingdong Huang*, A New Drug Binding Subsite on Human Serum   Albumin and Drug-Drug Interaction Studied by X-Ray Crystallography, Journal   of Structural Biology, 2008,   162(1): 40-49

38.     Qing   Huai, Aiwu Zhou, Lin Lin, Andrew P. Mazar, Graham C. Parry, Jennifer   Callahan, David E. Shaw, Bruce Furie, Barbara C. Furie, and Mingdong Huang*, Crystal Structures   of Two Human Vitronectin, Urokinase and Urokinase Receptor Complexes, Nature   Structural & Molecular Biology,   2008, 15(4): 422-23

39.     Gengxiang   Zhao, Cai Yuan, Troels Wind, Zixiang Huang, Peter A. Andreasen, and Mingdong Huang*, Structural Basis of   Specificity of a Peptidyl Urokinase Inhibitor, Upain-1, Journal of Structural   Biology, 2007, 160(1): 1-10

40.     Cai   Yuan, and Mingdong Huang*, Does   the Urokinase Receptor Exist in a Latent Form?, Cellular and Molecular Life   Sciences, 2007, 64(9): 1033-37

41.     Feng   Yang, Chuanbing Bian, Lili Zhu, Gengxiang Zhao, Zixiang Huang, and Mingdong Huang*, Effect of Human   Serum Albumin on Drug Metabolism: Structural Evidence of Esterase Activity of   Human Serum Albumin, Journal of Structural Biology, 2007, 157(2): 348-55

42.     Yongdong   Li, Graham Parry, Liqing Chen, Jennifer A. Callahan, David E. Shaw, Edward J.   Meehan, Andrew P. Mazar, and Mingdong   Huang*, An Anti-Urokinase Plasminogen Activator Receptor (Upar) Antibody:   Crystal Structure and Binding Epitope, Journal of Molecular Biology, 2007, 365(4): 1117-29

43.     Yijian   Rao, Chuanbing Bian, Cai Yuan, Yongdong Li, Liqing Chen, Xiaoming Ye, Zixiang   Huang, and Mingdong Huang*, An   Open Conformation of Switch I Revealed by Sar1-Gdp Crystal Structure at Low   Mg2+, Biochemical and Biophysical Research Communications, 2006, 348(3): 908-15

44.     Qing.   Huai, Andrew P. Mazar, Alice Kuo, Graham C. Parry, David E. Shaw, Jennifer   Callahan, Yongdong Li, Cai. Yuan, Chuanbing Bian, Liqing Chen, Bruce Furie,   Barbara C. Furie, Douglas B. Cines, and Mingdong   Huang*, Structure of Human Urokinase Plasminogen Activator in Complex   with Its Receptor, Science, 2006,   311(5761): 656-59

45.     Jincan   Chen, Naisheng Chen, Jinfing Huang, Jundong Wang, and Mingdong Huang*, Derivatizable Phthalocyanine with Single   Carboxyl Group: Synthesis and Purification, Inorganic Chemistry   Communications, 2006, 9(3): 313-15

获奖情况:

1. 福建省科技创新领军人才,2016年

2. 国务院政府特殊津贴,2013年

3. 国家级百千万人才工程,2007年

4. 国家杰出青年科学基金,2006年

5. 中科院百人计划,2003年

其他

国际合作:

1.   2008年起成立了《中国丹麦肿瘤和水解酶联合研究中心》(http://www.proteasesandcancer.org/chinese%20welcome.html)。丹麦是全世界创新力排名第五的国家,中丹共成立了十个联合研究中心,本中心为第一个中丹中心(http://www.nsfc.gov.cn/Portal0/InfoModule_396/25904.htm),本中心在第一期的资助结束后,2011年经过了国际范围的评估,得到了第二期资助。2013.5通过了丹麦国家研究基金委第二期资助的中期考核。多年来开展研究生联合培养,已有一人获得博士学位,两人获得丹麦奖学金在攻读丹麦博士学位,一人获得了丹麦的Danida奖金。

2.   获得中法先进研究项目和中法蔡元培基金的资助,共同开展研究工作和研究生联合培养。

3.   组织了多次国际会议,包括了2009年和2012年的中丹肿瘤和水解酶国际会议,以及2013年诺和诺德-中科院国际研讨会。应邀在多个国际会议上做大会邀请报告,包括了2006年第48届美国血液学年会、2006年第18届ISFP会议、2007年第21届ISTH(国际血栓和纤溶大会)、2007年International Workshop of Plasminogen Activation国际会议、2008年和2012年的Gordon   Research Conference on Plasminogen Activation。

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