生物科学与工程学院

College of Biological Science and Engineering

翁祖铨

发布日期:2020-10-08 发布者:生工学院

姓名:翁祖铨

性别:

职称:教授

学历:博士

电话:

电子邮件: wengzq@fzu.edu.cn

研究方向:智能医学、生物医药、食品药品安全性评价

教育工作经历:

1998年—2003年  福建医科大学,医学学士学位

2003年—2009年  日本国立大阪大学,医学博士学位

2009年—2011年  日本独立行政法人劳动安全卫生综合研究所 研究员

2012年—2015年     美国FDA国家毒理研究中心访问学者

教学简介:

讲授研究生课程:《天然活性分子的功能与健康》、《现代仪器分析》

讲授本科生课程:《药理学》、《食品生物技术》

科研简介:

翁祖铨博士现为福州大学生物科学与工程学院教授,“闽江学者”特聘教授,院长助理。主持或承担多项日本厚生劳动省,文部省,美国FDA的研究课题,中国国家自然基金,省部级重点课题,重大横向课题等,累积科研经费超过2200万。发表SCI文章41篇,合著科技专著2篇,申请国家发明专利11项,授权3项,实质审查8项。多次受邀参加国际学术会议,发表第一作者会议论文11篇。研究方向1、利用医疗大数据结合生物信息学,研究医疗智能教学、药物相互作用、智能检测诊断及预测;2、研究天然活性分子的保健功能和药效作用的机理及相关产品的研究和开发;3、食品药品安全检测技术的开发和危险性评价。

社会兼职:

1) 日本独立行政法人劳动安全卫生综合研究所客座研究员;

2) 中国工业毒理学会委员;

3) 中国营养学会公共营养分会委员;

4) 中国环境诱变剂学会生物标志物专业委员会委员;

5) 福建省食品安全地方标准审评委员会委员;

6) 福建省医养结合专家。

科研项目:

1) 福建省重大科技项目,福建省财政厅,83020008,烧创伤大数据研究中心平台建设,在研,主持

2) 中国国家自然科学基金委员会,面上项目,81971837,基因编辑斑马鱼促进烧伤创面修复再生的小鼠实验研究,在研,主持

3) 福建省重点项目,福建省财政厅,83020007,基于高分子材料与技术构建烧伤创面敷料,在研,主持

4) 重大横向课题,00801821,VR在烧伤救治方面的应用研究,在研,主持

5) 福州市科技计划项目,82318030,猪饲料污染物 - 玉米赤霉烯酮的检测试剂盒的研发,在研,主持

6) 福建省卫生教育联合攻关计划项目,83017000,酪氨酸激酶抑制剂类抗癌药的肝毒性分析及相关机理研究,在研,主持

7) 福州市科技计划项目,82316038,茶叶提取物-儿茶素功能性食品产业化的关键, 2结题,主持

8) 闽江学者(特聘教授)基金,510246,科研启动基金,结题,主持

代表性论文:

1)Yuanzi Wu, Shuigen Wu, Shanyun Ma, Fen Yan, and Zuquan Weng(通讯),Cytocompatible Modification of Thermoresponsive Polymers on Living Cells for Membrane Proteomic Isolation and Analysis. Analytic chemistry. 2019 Mar 5;91(5):3187-3194.

2)Tingfang Gao, Yuhong Shi,| Ying Xue, Fen Yan, Da Huang, Yuanzi Wu*, Zuquan Weng*(通讯). Polyphenol extract from superheated steam processed tea waste attenuates the oxidative damage in vivo and in vitro. J Food Biochem. 2019 Nov 6:e13096. doi: 10.1111/jfbc.13096.

3)Shuting Chen, Jie Wu, Qiang Tang, Chenlan Xu, Yan Huang, Da Huang, Fang Luo, Yuanzi Wu, Fen Yan, Zuquan Weng(通讯), Shaoyun Wang. Nano-micelles based on hydroxyethyl starch-curcumin conjugates for improved stability, antioxidant and anticancer activity of curcumin. Carbohydr Polym. 2020 Jan 15;228:115398. doi: 10.1016/j.carbpol.2019.115398. Epub 2019 Sep 30.

4)Zuquan Weng, Yuhong Shi, Megumi Suda, Yukie Yanagiba, Toshihiro Kawamoto, Tamie Nakajima, Rui-Sheng Wang, Inhalation Exposure to Low Levels of Ethyl tertiary Butyl Ether: Its Genetic Effects Were Significantly Modified by ALDH2 Activity. Environ Mol Mutagen. 2019 Mar;60(2):145-153.

5)Wang H, Chen J, Suda M, Yanagiba Y, Weng Z(通讯), Wang RS. Acute inhalation co-exposure to 1,2-dichloropropane and dichloromethane cause liver damage by inhibiting mitochondrial respiration and defense ability in mice. J Appl Toxicol. 2019 Feb;39(2):260-270. doi: 10.1002/jat.3715. 

6)Lin J, Wang H, Yan F, Tang K, Zhu H, Weng Z(通讯), Wang K. Effects of occupational exposure to noise and dust on blood pressure in Chinese industrial workers. Clin Exp Hypertens. 2018;40(3):257-261. doi: 10.1080/10641963.2017.1368534. Epub 2017 Oct 31. 

7)Zhang Y, Wang L, Luo F, Qiu B, Guo L, Weng Z(通讯), Lin Z, Chen G. An electrochemiluminescence biosensor for Kras mutations based on locked nucleic acid functionalized DNA walkers and hyperbranched rolling circle amplification. Chem Commun (Camb). 2017 Mar 7;53(20):2910-2913. doi: 10.1039/c7cc00009j. 

8)Weng Z, Suda M, Wan M, Zhang X, Guan D, Zhao P, Zheng Y, Miyagawa M, Wang RS. Significant association between decreased ALDH2 activity and increased sensitivity to genotoxic effects in workers occupationally exposed to styrene. Oncotarget. 2016 Jun 21;7(25):38224-38234. doi: 18632/oncotarget.9502. 

9)Wang K, Wan M, Wang RS, Weng Z(通讯). Opportunities for Web-based Drug Repositioning: Searching for Potential Antihypertensive Agents with Hypotension Adverse Events. J Med Internet Res. 2016 Apr 1;18(4):e76. doi: 10.2196/jmir.4541. 

10)Jiamin Chen, Yuanzi Wu, Fen Yan, Da Huang, andZuquan Weng(通讯), A fluorescent biosensor based on catalytic activity of platinum nanoparticles for rapid detection of hypoxanthine in aquatic products. Food Chem. 2020 Apr 25;310:125922. doi: 10.1016/j.foodchem.2019.125922. Epub 2019 Dec 4.

11)Liping Lin, Chenlan Xu, Yuehan Zhang, Zuquan Weng(通讯), Rui-Sheng Wang, ALDH2 deficiency significantly exacerbates tertiary butyl alcohol-induced toxicity in mice. J Appl Toxicol. 2020 Jul;40(7):979-990. doi: 10.1002/jat.3957. Epub 2020 Feb 14.

12)Xiaobin Liu, Danhua Zheng, Yi Zhong, Zhaofan Xia, Heng Luo, and Zuquan Weng(通讯), Machine learning prediction of oral drug-induced liver injury (DILI) via multiple features and endpoints. Biomed Res Int. 2020 May 19;2020:4795140. doi: 10.1155/2020/4795140.

13)Weng Z, Wang K, Li H, Shi Q. A comprehensive study of the association between drug hepatotoxicity and daily dose, liver metabolism, and lipophilicity using 975 oral medications. Oncotarget. 2015 6(19):17031-8.

14)Weng Z, Luo Y, Yang X, Greenhaw J, Xie L, Mattes W, Mendrick D, Shi Q. Regorafenib at clinically relevant concentrations impairs mitochondrial functions causing necrosis but not apoptosis in primary rat hepatocytes. Toxicology 2015 327:10-21.

15)Weng Z, Ohtani K, Suda M, Yanagiba Y, Kawamoto T, Nakajima T, Wang RS. Assessment of the reproductive toxicity of inhalation exposure to Ethyl tertiary Butyl Ether in male mice with normal, low active and inactive ALDH2. Arch Toxicol. 2014 88(4): 1007-1021.

16)Weng Z, Zhou P, Salminen WF, Yang X, Harrill AH, Cao Z, Mattes WB, Mendrick DL, Shi Q Green tea epigallocatechin gallate binds to and inhibits respiratory complexes in swelling but not normal rat hepatic mitochondria. Biochem Biophys Res Commun. 2014 443(3): 1097-1104.

17)Weng Z, Suda M, Ohtani K, Mei N, Kawamoto T, Nakajima T, Wang RS. Subchronic Exposure to Ethyl tertiary Butyl Ether Resulting in Genetic Damage in Aldh2 Knockout Mice. Toxicology. 2013 311(3):107-114.

18)Weng Z, Greenhaw J, Salminen WF, Shi Q. Mechanisms for epigallocatechin gallate induced inhibition of drug metabolizing enzymes in rat liver microsomes. 2012 Toxicol Lett. 214(3):328-338.

19)Weng Z, Suda M, Ohtani K, Mei N, Kawamoto T, Nakajima T, Wang RS. Differential Genotoxic Effects of Subchronic Exposure to Ethyl Tertiary Butyl Ether in the Livers of Aldh2 Knockout and Wild-type Mice. Arch Toxicol. 2012 86(4):675-682.

20)Weng Z, Suda M, Ohtani K, Mei N, Kawamoto T, Nakajima T, Wang RS. Aldh2 Knockout Mice Were More Sensitive to DNA Damage in Leukocytes due to Ethyl Tertiary Butyl Ether Exposure. Ind Health. 2011 49(3):396-399.

21)Weng H, Weng Z(共同第一作者), Lu Y, Nakayama K, Morimoto K. Effects of alcohol-drinking behaviour and ADH1B and ALDH2 polymorphisms on basal DNA damage in human mononuclear cells as determined by the comet assay. Mutat Res. 2010 701:132-136.

22)Weng H, Weng Z(共同第一作者), Lu Y, Nakayama K, Morimoto K. Effects of cigarette smoking, XRCC1 genetic polymorphisms, and age on basal DNA damage in human blood mononuclear cells. Mutat Res. 2009 679:59-64.  

23)Weng Z, Lu Y, Weng H, Morimoto K. Effects of the XRCC1 gene-environment interactions on DNA damage in healthy Japanese workers. Environ Mol Mutagen. 2008 49:708-719.

获奖情况:

1) 2012年获得日本第82届卫生学会年度总会议最优秀论文奖;

2) 2015年11月被授予福建省“闽江学者”特聘教授称号;

3) 2016年5月被评为2015-2016学年福州大学创新创业活动优秀指导教师;

4) 2017年4月获得福州大学青年五四奖章;

5) 2018年8月第三届全国大学生生命科学创新创业大赛指导教师一等奖;

6) 2019年度第二届福州大学“福能奖教金”获得者。

其他