职务：研究员/硕士生导师

学历：博士

电子邮件：

wmmj0419@163.com

W1833@fzu.edu.cn

主要研究方向：肿瘤分子影像、抗肿瘤纳米药物、肿瘤免疫治疗

教育工作经历：

1.2003/9–2007/6，武汉工程大学，应用化学，学士

2.2007/9–2013/6，武汉大学，高分子化学与物理，博士（硕博连读）

3.2013/10-2017/1，福建医科大学孟超肝胆医院，助理研究员

4.2017/2–2020/6，福建医科大学孟超肝胆医院，副研究员

5.2020/7至今，福建医科大学孟超肝胆医院，研究员

6.2018/2至今，福州大学孟超医学与交叉科学中心，硕士生导师

科研简介：针对肝癌早期诊断困难、治疗手段匮乏、疗效不佳等瓶颈问题，开发基于功能生物材料的载体系统，实现小分子化疗药物、siRNA/CRISPR-Cas9/核酸疫苗等靶向递送，用于肝癌的低毒、高效治疗。已在Advanced Science, Molecular Therapy, iScience, Nano-Micro Letters, Theranostics, Advanced Healthcare Materials等国际刊物发表SCI论文30余篇。主持国家自然科学基金青年基金、中国博士后面上资助、福建省卫生教育联合攻关项目、福建省自然科学基金、福建省科技创新联合资金项目、福建省卫计委中青年骨干人才培养项目、福建省卫计委青年科研课题、福州市科技计划项目等多个项目。入选“福建省高层次人才”，“福建省青年拔尖人才”，“福州市高层次引进人才”，“福州市闽都英才”等计划。

社会兼职：福州大学硕士生导师、武汉工程大学硕士生导师、中国抗癌协会抗癌药物专业委员会青年委员、福建省医学会外科学分会实验外科与转化医学学组委员。

科研项目：

1. 福州市对外科技合作项目，2022-Y-007，靶向PD-L1的CRISPR/Cas9腺病毒系统在肿瘤免疫治疗中的应用，2022.6-2024.6，30万元。

2. 福建省自然科学基金，2022J011282，拮抗VEGF和PD-L1的仿生纳米囊泡用于肝癌免疫治疗的研究，2022.8-2025.8，7万元。

3. 福州市科技创新创业人才培育计划项目，2021-R-105，基于细胞膜囊泡的肝癌免疫治疗新策略研究，2021.6-2023.5，30万元。

4. 福州市卫健委创新团队项目，2020-S-wt7，细胞膜材料在肿瘤免疫抑制性微环境调控中的研究，2020.10-2023.10，8万元。

5. 福建省科技创新联合资金项目，2019Y9046，细胞源性微囊泡协同增强抗肿瘤免疫效应，2020.9-2023.8，30万元。

6. 福建省卫生教育联合攻关计划项目，2019-WJ-20，生物来源纳米囊泡在肿瘤免疫治疗中的研究，2019/12-2022/12，20万元。

7. 国家自然科学基金青年基金，81601538，肿瘤信号分子触发化学发光/超声双模成像和光动力治疗的新型纳米探针研究，2017/01-2019/12，17万元。

8. 中国博士后面上二等资助，2015M571959，双重响应性纳米药物载体用于靶向治疗肝癌的研究，2015/06-2016/12，5万元。

9. 福建省自然科学基金青年创新项目，2015J05175，肿瘤微环境触发靶向定位的磁共振影像纳米探针的研究，2015/04-2018/04，3万元。

10. 福建省科技创新联合资金项目，2016Y9061，肿瘤信号分子触发“诊疗一体化”纳米探针的研究，2016/09-2019/09，10万元。

11. 福建省卫计委青年科研课题，2014-1-75，基于智能电荷翻转和还原响应性双功能聚合物纳米粒输送化疗药物的研究，2015/01-2017/01，3万元。

12. 福建省卫计委中青年骨干人才培养项目，2017-ZQN-75，化学发光用于肿瘤光动力治疗的研究，2017/09-2020/08，10万元。

13. 福州市科技计划项目，2014-S-139-6，新型聚乙二醇衍生物用于化疗药物的肝癌靶向可控输送研究，2014/07-2017/07，5万元。

已发表论文：（^#为第一作者，*为通讯作者）

(1) Lei Ding^#, Xiaolong Zhang^#, Peiwen Yu, Fang Peng, Yupeng Sun, Yanni Wu, Zijin Luo, Hongsheng Li, Yongyi Zeng, Ming Wu*, Xiaolong Liu*, Genetically Engineered Nanovesicles Mobilize Synergistic Antitumor Immunity by ADAR1 Silence and PDL1 Blockade, Molecular Therapy, 2023, DOI:10.1016/j.ymthe.2023.04.011.

(2) Ming Wu^#, Hao Li^#, Cao Zhang^#, Yingchao Wang^#, Cuilin Zhang, Yuting Zhang, Aoxue Zhong, Da Zhang*, Xiaolong Liu*, Silk-gel powered adenoviral vector enables robust genome editing of PD-L1 to augment immunotherapy across multiple tumor models, Advanced Science, 2023, 10, 2206399.

(3) Yiru Wang^#, Ming Wu^#, Xiaorong Wang^#, Peiyuan Wang, Zhaoyu Ning, Yongyi Zeng, Xiaolong Liu, Haiyan Sun*, Aixian Zheng*, Biodegradable MnO₂-based gene-engineered nanocomposites for chemodynamic therapy and enhanced antitumor immunity, Materials Today Bio, 2023, 18, 100531.

(4) Qianqian Mao^#, Juan Min^#, Rui Zeng^#, Haiqin Liu, Hao Li, Cao Zhang, Aixian Zheng, Jiumao Lin*, Xiaolong Liu*, Ming Wu*, Self-assembled traditional Chinese nanomedicine modulating tumor immunosuppressive microenvironment for colorectal cancer immunotherapy, Theranostics, 2022, 12, 6088-6105. *

(5) Mingbin Huang^#, Chao Xu^#, Sen Yang, Ziqian Zhang, Zuwu Wei*, Ming Wu*, Fangqin Xue*, Vehicle-Free Nanotheranostic Self-Assembled from Clinically Approved Dyes for Cancer Fluorescence Imaging and Photothermal/Photodynamic Combinational Therapy, Pharmaceutics, 2022, 14, 1074.

(6) Yanbing Cao^#, De Wei^#, Lixia Yang^#, Zijin Luo, Peiwen Yu, Hao Li, Cao Zhang, Xiaolong Liu, Fengshou Wu*, Ming Wu*, Yongyi Zeng*, Nanoplatform Self-Assembly from Small Molecules of Porphyrin Derivatives for NIR-II Fluorescence Imaging Guided Photothermal-Immunotherapy, Advanced Healthcare Materials, 2022, 11, 2102526.

(7) Jiong Li^#, Sijia Wang^#, Xinyi Lin, Yanbing Cao, Zhixiong Cai, Jing Wang, Zhenxi Zhang, Xiaolong Liu, Ming Wu*, Cuiping Yao*, Red blood cell‑mimic nanocatalyst triggering radical storm to augment cancer immunotherapy, Nano-Micro Letters, 2022, 14, 57.

(8) Da Zhang^#, Ziguo Lin^#, Ming Wu^#, Zhixiong Cai, Youshi Zheng, Lei He, Zhenli Li, Jie Zhou, Liqin Sun, Geng Chen, Yongyi Zeng, Juan Li, Jingfeng Liu*, Huanghao Yang*, Xiaolong Liu*, Cytosolic Delivery of Thiolated Neoantigen Nano-Vaccine Combined with Immune Checkpoint Blockade to Boost Anti-Cancer T Cell Immunity, Advanced Science, 2021, 8, 2003504.

(9) Peiwen Yu^#, Dongye Zheng^#, Cuilin Zhang, Ming Wu*, Xiaolong Liu*, Protocol to prepare functional cellular nanovesicles with PD1 and TRAIL to boost antitumor response, Star Protocols, 2021, 2, 100324.

(10) Fangqin Xue, XiaoLin, Zhixiong Cai, Xiaolong Liu, Yuan Ma*, MingWu*, Doxifluridine-based pharmacosomes delivering miR-122 as tumor microenvironments-activated nanoplatforms for synergistic treatment of hepatocellular carcinoma, Colloids and Surfaces B: Biointerfaces, 2021, 197, 111367.

(11) Haolan Li, Liangliang Yue, Ming Wu*, Fengshou Wu*, Self-assembly of methylene violet-conjugated perylene diimide with photodynamic/photothermal properties for DNA photocleavage and cancer treatment, Colloids and Surfaces B: Biointerfaces, 2020, 196, 111351.

(12) Ming Wu^#, Dongye Zheng^#, Da Zhang^#, Peiwen Yu, Lianli Peng, Feng Chen, Ziguo Lin, Zhixiong Cai, Jiong Li, Zuwu Wei, Xinyi Lin, Jingfeng Liu*, Xiaolong Liu*, Converting immune cold into hot by biosynthetic functional vesicles to boost systematic antitumor immunity, iScience, 2020, 23, 101341.

(13) Dongye Zheng^#, Peiwen Yu^#, Zuwu Wei, Cheng Zhong, Ming Wu*, Xiaolong Liu*, RBC membrane camoufaged semiconducting polymer nanoparticles for near‑infrared photoacoustic imaging and photothermal therapy, Nano-Micro Letters, 2020, 12, 94.

(14) Kecan Lin^#, Yanbing Cao^#, Dongye Zheng, Qin Li, Hui Liu, Peiwen Yu, Jiong Li, Yanan Xue，Ming Wu*, Facile phase transfer of hydrophobic Fe₃O₄@Cu_2-xS nanoparticles by red blood cell membrane for MRI and phototherapy in the second near-infrared window, Journal of Materials Chemistry B, 2020, 8, 1202-1211.

(15) Xiao Lin, Xiaofang Song, Yiwei Zhang, Yanbing Cao, Yanan Xue, Fengshou Wu, Faquan Yu*, Ming Wu*, Xunjin Zhu*, Multifunctional theranostic nanosystems enabling photothermal-chemo combination therapy of triple-stimuli-responsive drug release with magnetic resonance imaging, Biomaterials Science, 2020, 8,1875-1884.

(16) Xiao Lin, Yanbing Cao, Yanan Xue, Fengshou Wu, Faquan Yu*, Ming Wu*, Xunjin Zhu*, Multifunctional theranostic agents based on prussian blue nanoparticles for tumor targeted and MRI-guided photodynamic/photothermal combined treatment, Nanotechnology, 2020, 31, 135101.

(17) Yanbing Cao^#, Juan Min^#, Dongye Zheng, Jiong Li, Yanan Xue*, Faquan Yu*, Ming Wu*, Vehicle-saving theranostic probes based on hydrophobic iron oxide nanoclusters using doxorubicin as a phase transfer agent for MRI and chemotherapy, Chemical Communications, 2019, 55, 9015-9018.

(18) Xiao Lin, Yanbin Cao, Jiong Li, Dongye Zheng, Shanyou Lan, Yanan Xue, Faquan Yu*, Ming Wu*, Xunjin Zhu*, Folic acid-modified Prussian blue/polydopamine nanoparticles as an MRI agent for use in targeted chemo/photothermal therapy, Biomaterials Science, 2019, 7, 2996-3006.

(19) Jiong Li^#, Zuwu Wei^#, Xinyi Lin, Dongye Zheng, Ming Wu*, Xiaolong Liu*, Jingfeng Liu*, Programmable therapeutic nanodevices with circular amplification of H₂O₂ in the tumor microenvironment for synergistic cancer therapy, Advanced Healthcare Materials, 2019, 8, 1801627.

(20) Ming Wu, Lingjie Wu, Jiong Li, Da Zhang, Shanyou Lan, Xiaolong Zhang, Xinyi Lin, Gang Liu, Xiaolong Liu*, Jingfeng Liu*, Self-luminescing theranostic nanoreactors with intraparticle relayed energy transfer for tumor microenvironment activated imaging and photodynamic therapy, Theranostics, 2019, 9, 20-33.

(21) Xinyi Lin^#, Ming Wu^#, Ming Li, Zhixiong Cai, Haiyan Sun, Xionghong Tan,  Jiong Li, Yongyi Zeng, Xiaolong Liu*, Jingfeng Liu*, Photo-responsive hollow silica nanoparticles for light-triggered genetic and photodynamic synergistic therapy, Acta Biomaterialia, 2018, 76, 178-192.

(22) Ming Wu^#, Xinyi Lin^#, Da Zhang, Youshi Zheng, Ai-Xian Zheng, Bixing Zhao, Yongyi Zeng, Xiaolong Liu*, Jingfeng Liu*, Photoresponsive nanovehicle for two independent wavelength light-triggered sequential release of P-gp shRNA and doxorubicin to optimize and enhance synergistic therapy of multidrug-resistant cancer, ACS Applied Materials & Interfaces, 2018, 10, 19416-19427.

(23) Jiong Li, Xuandong Wang, Dongye Zheng, Xinyi Lin, Zuwu Wei, Da Zhang, Zhuanfang Li, Yun Zhang, Ming Wu*, Xiaolong Liu*, Cancer cell membrane-coated magnetic nanoparticles for MR/NIR fluorescence dual-modal imaging and photodynamic therapy, Biomaterials Science, 2018, 6, 1834-1845.

(24) Ming Wu^#, Jiong Li^#, Xinyi Lin, Zuwu Wei, Da Zhang, Bixing Zhao, Xiaolong Liu*, Jingfeng Liu*, Reduction/photo dual-responsive polymeric prodrug nanoparticles for programmed siRNA and doxorubicin delivery, Biomaterials Science, 2018, 6, 1457-1468.

(25) Cuiping Yao^#, Ming Wu^#*, Cecheng Zhang, Xinyi Lin, Zuwu Wei, Youshi Zheng, Da Zhang, Zhenxi Zhang*, Xiaolong Liu*, Photoresponsive lipid-polymer hybrid nanoparticles for controlled doxorubicin release, Nanotechnology, 2017, 28, 255101.

(26) Lingjie Wu^#, Ming Wu^#, Xinyi Lin, Xiaolong Zhang, Xiaolong Liu*, Jingfeng Liu*, Magnetite nanocluster and paclitaxel loaded charge-switchable nanohybrids for MR Imaging and chemotherapy, Journal of Materials Chemistry B, 2017, 5: 849-857.

(27) Ming Wu, Qingtang Wang, Da Zhang, Naishun Liao, Lingjie Wu, Aimin Huang, Xiaolong Liu*, Magnetite nanocluster@poly(dopamine)-PEG@indocyanine green  nanobead with magnetic field-targeting enhanced MR imaging and photothermal therapy in vivo, Colloids and Surfaces B: Biointerfaces, 2016, 141, 467-475.

(28) Ming Wu, Da Zhang, Yongyi Zeng, Lingjie Wu, Xiaolong Liu*, Jingfeng Liu*, Nanocluster of superparamagnetic iron oxide nanoparticles coated with poly (dopamine) for magnetic field-targeting, highly sensitive MRI and photothermal cancer therapy, Nanotechnology, 2015, 26: 115102.（2015年度热点论文）

(29) Ming Wu^#, Qingtang Wang^#, Xiaolong Liu*, Jingfeng Liu*, Highly efficient loading of doxorubicin in Prussian Blue nanocages for combined photothermal/chemotherapy against hepatocellular carcinoma, RSC Advances, 2015, 5, 30970-30980.

(30) Lingjie Wu^#, Ming Wu^#, Yongyi Zeng, Da Zhang, Aixian Zheng, Xiaolong Liu*, Jingfeng Liu*, Multifunctional PEG modified DOX loaded mesoporous silica nanoparticle@CuS nanohybrids as photo-thermal agent and thermal-triggered drug release vehicle for hepatocellular carcinoma treatment, Nanotechnology, 2015, 26, 025102.

授权发明专利：

(1) 发明人：吴名; 张达; 刘小龙; 刘景丰; 曾永毅; 用于声动力/气体协同抗肿瘤治疗的仿生纳米材料及其制备. 授权号：ZL202010555452.1

(2) 发明人：吴名; 刘景丰; 刘小龙; 曾永毅; 一种具有光响应降解的瘤可宁前体化合物及其制备与应用.授权号：ZL201710608245.6

获奖情况

福建省科技进步一等奖（7/10）. 2022

福建省自然科学优秀学术论文三等奖（1/2）. 2022

福建省医学科技二等奖（3/7）. 2020

福建省自然科学优秀学术论文二等奖（1/1）. 2018

英国物理学会“China Top Cited Author Award”（1/2）. 2018