职称：教授，博士生导师

学历：博士研究生

电子邮件: lijingying@fzu.edu.cn

研究方向：纳米生物分析；纳米医药；活细胞成像

职务：生物医学工程系党支部书记

地址：福州大学旗山校区国家大学科技园7号楼

教育工作经历：

2006.09-2010.07   中国农业大学 化学专业 学士

2010.09-2015. 07   国家纳米科学中心 物理化学专业 博士

2015.08-2019.07   福州大学生物科学与工程学院 讲师

2019.07-2025.08  福州大学生物科学与工程学院 副教授

2025.08至今      福州大学生物科学与工程学院 教授

科研简介：

从事基于功能纳米材料、功能核酸的生物探针构建以及在生物检测、细胞生物学等领域的应用研究，包括活细胞荧光成像、细胞膜蛋白调控、肿瘤靶向检测及诊断等。目前已在Journal of the American Chemical Society、Angewandte Chemie International Edition、Analytical Chemistry等国际刊物发表SCI论文20余篇。先后主持国家自然科学基金面上项目、福建省杰出青年科学基金、技术开发横向合作项目等近10项，科研成果已实现成果转化及应用。入选福建省第五批“雏鹰计划”青年拔尖人才、福建省高层次C类人才、福州大学“旗山学者”。获第八届中国国际“互联网+”大学生创新创业大赛银奖、福建省“互联网+”大学生创新创业大赛优秀创新创业导师、福州大学“青年五四奖章”、福州大学“杰出青年教师励志奖”等荣誉称号。

科研项目：

多级联靶标响应型动态DNA纳米探针用于原位肝癌活体成像，国家自然科学基金面上项目，2025-2028，主持。

活细胞表面特定蛋白糖基化类型的高通量分析及其分子识别性能的研究，国家自然科学基金面上项目，2020-2023，主持。

基于GaN纳米结构的乳腺癌CTC分离及差异蛋白SALDI-MS分析研究，国家自然科学基金青年基金项目，2017-2019，主持。

活细胞膜蛋白功能分析及其应用，福建省杰出青年科学基金，2023-2026，主持。

基于硫醇交换递送系统的纳米药物，技术转让，2021-2022，主持。

靶向肿瘤转移节点分子的多模块可编程纳米药物，国家重点研发计划，2020-2025，参与。

代表性学术论文：

1. Zhijie Lian, Lingying Zheng, Shuya Liu, Junjie Zhang, Jie Zhou, Junjun Wu, Songying Ouyang, Jingying Li,* and Huanghao Yang*; Breaking Endosomal Barriers: Thiol-Mediated Uptake Lipid Nanoparticles for Efficient mRNA Vaccine Delivery, Journal of the American Chemical Society, 2025, 147, 31530−31540.

2. Shuya Liu, Shiwei Li, Jirong Lin, Jingying Li,* Huanghao Yang*; Aptamer-InducedDimerization Strategy Attenuates AβO Toxicity through Modulating the Trophic Activity of PrP^C Signaling, Journal of the American Chemical Society, 2022, 144(21): 9264-9270.

3. Shan Chen, Zhifei Xu, Shiwei Li, Hong Liang, Chen Zhang, Zonghua Wang, Jingying Li,* Juan Li, and Huanghao Yang*; Systematic Interrogation of Cellular Signaling in Live Cells Using a Membrane-Anchored DNA Multitasking Processor, Angewandte Chemie International Edition, 2022, 61, e202113795.

4. Jingying Li, Shuya Liu, Liqin Sun, Wei Li, Su-Yun Zhuang, Sheng Yang, Juan Li*, Huang-Hao Yang*; Amplified Visualization of Protein-Specific Glycosylation in Zebrafish via Proximity-Induced Hybridization Chain Reaction, Journal of the American Chemical Society, 2018, 140, 16589.

5. Shuya Liu, Dongliang Wang, Sishi Ye, Junjie Zhang, Beiyan Du, Zhijie Lian, Wen Yang, Jie Zhou, Qi Chen, Juan Li,* Jingying Li,* and Huanghao Yang*; Disulfide-Appended siRNA Nanoeyedrops:Noninvasive Gene Therapy for Targeting Retinal Angiogenesis, ACS Nano, 2025, 19, 35333−35347.

6. Lei Li,, Jing Hu, Wen Yang *, Jingying Li*; Tumor-specific glyco-detonators: A neuraminidase-3-gated programmable DNA Nanoarchitectonics for liver cancer-exclusive chemotherapy, Journal of Controlled Release, 2026, 390, 114495.

7. Shan Chen, Yufei Zhuo, Liying Pang, Hong Liang, Xiahui Lin,* and Jingying Li*; Photoactivatable DNA Conveyer Ferries Cellular Receptors to Lysosome for Collaborative Degradation in Zebrafish, ACS Applied Materials Interfaces, DOI: 10.1021/acsami.5c20326.

8. Shuya Liu, Lubin Han, Wen Yang, Bing Xiao, and Jingying Li*; Molecular-Specific Optical Coherence Tomography Contrast Agents for High-Sensitivity In Vivo Detection of Corneal Injury, ACS Sensors. 2025, 10, 9225-9231.

9. Shan Chen, Yufei Zhuo, and Jingying Li*; Nucleic Acid-based Protein Labeling Tools for Visualization of Membrane Receptors, Chem. J. Chinese Universities, 2025, 46(7), 20240567.

10. Junjie Zhang, Changkun Peng, Shuya Liu, Zhijie Lian, Jie Zhou, Jingying Li,* Huanghao Yang*; A Self-Assembled Transdermal Nanomedicines Incorporating Pendant Disulfides for Non-Invasive, Synergistic Treatment of Melanoma, Advanced Healthcare Materials, 2024, 13, 2402685.

11. Junjie Zhang, Weican Sun, Xing Wang, Senyan Chen, Jingying Li,* Huanghao Yang*; Thiol-mediated transportation pathway: an approach for improving tumor penetration of nanomedicines in vivo, Science China-Chemistry, 2024, 67, 383-389.

12. Jie Zhou, Junjie Zhang, Senyan Chen, Qinghua Lin, Rong Zhu, Liping Wang, Xiaole Chen, Jingying Li,* Huanghao Yang; Direct cytoplasmic delivery of RNAi therapeutics through a nonlysosomal pathway for enhanced gene therapy, Acta Biomaterialia, 2023, 170, 401-414.

13. Wen Yang, Zixiang Huang, Zhifei Xu, Xin Ma, Shan Huang, Jingying Li,* Juan Li, and Huanghao Yang; Selective and Nongenetic Peroxidase Tag of Membrane Protein: a Nucleic Acid Tool for Proximity Labeling, Analytical Chemistry, 2022, 94, 1101.

14. Wen Yang, Hexin Nan, Zhifei Xu, Zixiang Huang, Shan Chen, Jingying Li*, Juan Li, and Huanghao Yang*; DNA-Templated Glycan Labeling for Monitoring Receptor Spatial Distribution in Living Cells, Analytical Chemistry, 2021, 93, 12265.

15. Junjie Zhang, Hui Yang, Liang Li, Changkun Peng, and Jingying Li*; Noninvasive Transdermal Delivery of STING Agonists Reshapes the Immune Microenvironment of Melanoma and Potentiates Checkpoint Blockade Therapy Efficacy, ACS Applied Bio Materials, 2025, 8, 3156-3166.

16. Shuya Liu, Zhike Yan, Zixiang Huang, Huanghao Yang,* Jingying Li*; Smart Nanocarriers for the Treatment of Retinal Diseases, ACS Applied Bio Materials, 2024, 7, 2070−2085.

17. Lei Li, Jingying Li*; Dimerization of Transmembrane Proteins in Cancer Immunotherapy, Membranes, 2023, 13, 393.

18. Jingying Li, Liping Wang, Jinmiao Tian, Zhilan Zhou, Juan Li* and Huanghao Yang*; Nongenetic engineering strategies for regulating receptor oligomerization in living cells, Chemical Society Reviews, 2020, 49, 1545.

19. Jingying Li⁺, Tong Liu⁺, Shuya Liu, Juan Li*, Guoming Huang*, Huang-Hao Yang; Bifunctional magnetic nanoparticles for efficient cholesterol detection and elimination via host-guest chemistry in real samples, Biosensors & Bioelectronics, 2018, 120, 137.

20. Jingying Li⁺, Jie Zhou⁺, Tong Liu, Shan Chen, Juan Li* and Huanghao Yang*; Circular DNA: A Stable Probe for High Efficient mRNA Imaging and Gene Therapy in Living Cells. Chemical Communications, 2018, 54, 896.

21. Guoming Huang, Rui Liu, Yuehua Hu, Shi-Hua Li, Ying Wu, Yuan Qiu, Jingying Li*, Huanghao Yang; FeOOH-Loaded Mesoporous Silica Nanoparticles as A Theranostic Platform with pH-Responsive MRI Contrast Enhancement and Drug Release. Science China-Chemistry, 2018, 61, 806.