生物科学与工程学院

College of Biological Science and Engineering

黄达

发布日期:2024-11-13 发布者:

姓名:黄达

性别:


职称:副教授

学历:博士

QQ122636859

电子邮件:huangda@fzu.edu.cn

研究方向:生物医用材料

招生专业(方向):生物医学工程(学硕)、生物工程(学硕)、生物技术与工程(专硕)

教育工作经历:

2017.08-至今 福州大学生物科学与工程学院,讲师/副教授,硕士生导师

2020.02-2022.07 美国弗吉尼亚联邦大学/密苏里科技大学,博士后

2014.09-2017.07 中国科学院化学研究所,高分子化学与物理,博士

2011.09-2014.07 中国科学院化学研究所,材料工程,硕士

2007.09-2011.07 北京化工大学,高分子材料与工程,本科

教学简介:

本科生课程:《药物化学与药物分析》、《药剂学》、《生物高分子与胶体》、《生物医学纳米技术》

研究生课程:《纳米生物技术》、《药物递送系统》、《高分子与胶体化学》、《天然活性分子的功能与健康》

科研简介:

主要从事生物医用材料的设计制备及应用研究,包括(1)纳米药物递送系统的构建及其在炎症性疾病治疗方面的应用;(2)医用水凝胶的制备及其在抗感染伤口敷料、软骨修复等方面的应用;(3)可降解医用支架的制备及其在骨修复领域的应用;(4)检测疾病标志物的生物传感器的开发及应用。目前已在Angewandte ChemieAdvanced Science、Biomaterials、Advanced Healthcare Materials、Carbohydrate Polymers、Biosensors & Bioelectronics等本领域知名国际期刊上发表SCI论文40余篇,其中第一作者和通讯作者论文20余篇,授权发明专利4项。

社会兼职:

1)2022.06至今,担任Frontiers in Bioengineering and Biotechnology: Biomaterials期刊审稿编辑

2)担任Carbohydrate PolymersInternational Journal of PharmaceuticsMaterials Today BioInternational Journal of Biological MacromoleculesFood Chemistry、Biomaterials ScienceJournal of Materials Chemistry B等国际学术期刊审稿人

3)福建省福州市/莆田市科技特派员。

科研项目:

1)福建省自然科学基金面上项目,兼具活性氧清除和多药递送功能的羟乙基淀粉-姜黄素微粒的制备及其用于炎症性肠病治疗的研究,2023-2026,主持

2)福建省自然科学基金青年项目,酸响应多级释放纳米载体用于抗癌药物传输的研究,2019-2022,主持

3)福建省教育厅中青年教师项目,姜黄素-茶多酚纳米药物的制备及应用,2018-2020,主持

4)福州大学科研启动经费,利用茶多酚制备疏水药物的新型纳米制剂的研究,2017-2020,主持

5)技术服务项目,透明质酸水凝胶的制备和表征,2024-2026,主持

6)技术开发项目,基于体表肿瘤、慢性创面与脂肪组织工程等整形外科亚专业的临床与基础研究,2023-2026,主持

7)技术开发项目,纳米均孔膜的均相电化学发光传感器的技术开发,2023-2025,主持

8)技术开发项目,氢气饱和生理盐水纳米铂的制备及应用,2020-2022,主持

9)国家自然科学基金面上项目,高稳定性新型全无机无铅钙钛矿纳米材料的合成及应用,2023-2026,参与(第二)

10)建省科技厅合作项目,基于金纳米团簇/二氧化钛光催化材料的制备及其创面抗菌作用的研究,2022-2025,参与(第二)

代表性论文:(*为通讯作者)

1. Zhichao Yu, Zhenjin Xu, Ruijin Zeng, Man Xu, Haisu Zheng, Da Huang,* Zuquan Weng* and Dianping Tang.* D-band center engineered Pt-based nanozyme for personalized pharmacovigilance. Angewandte Chemie International Edition 2024, e202414625. IF=16.1

2. Da Huang, Pedro Norat, Lin Qi, Anna Chernatynskaya, James D. Cole, Vimalin Jeyalatha Mani, Lei Xu, Xiaorong Liu,* and Hu Yang.* Consistent intraocular pressure reduction by solid drug nanoparticles in fixed combinations for glaucoma therapy. Advanced Science 2024, 2401648. IF=14.3

3. Da Huang, Yongming Wang, Chenlan Xu, Minglang Zou, Yangcan Ming, Fang Luo, Zhenjin Xu, Ying Miao, Na Wang,* Zhenyu Lin, Zuquan Weng.* Colon-targeted hydroxyethyl starch-curcumin microspheres with high loading capacity ameliorate ulcerative colitis via alleviating oxidative stress, regulating inflammation, and modulating gut microbiota. International Journal of Biological Macromolecules 2024, 266, 131107. IF=8.4

4. Da Huang, Jiahao Du, Fang Luo, Gang He, Minglang Zou, Yongming Wang, Zhenyu Lin,* Decheng Wu,* and Zuquan Weng.* Injectable hydrogels with integrated pH probes and ultrasound-responsive microcapsules as smart wound dressings for visual monitoring and on-demand treatment of chronic wounds. Advanced Healthcare Materials 2024, 2303379. IF=10

5. Da Huang, Minglang Zou, Chenlan Xu, Yongming Wang, Zhenjin Xu, Wancong Zhang,* Shijie Tang,* and Zuquan Weng.* Colon-targeted oral delivery of hydroxyethyl starch-curcumin microcapsules loaded with multiple drugs alleviate DSS-induced ulcerative colitis in mice. Macromolecular Bioscience 2024, 2300465. IF=4.6

6. Da Huang,* Qiang Tang, Minglang Zou, Yongming Wang, Fang Luo, Jinyi Mu, Yuanzi Wu, Zuquan Weng* and Zhenyu Lin. Anti-inflammatory unimolecular micelles of redox-responsive hyperbranched polycurcumin amphiphiles with enhanced anti-inflammatory efficacy in vitro and in vivo. Polymer Chemistry 2023, 14, 5208-5217. IF=5.364

7. Chenlan Xu, Shuting Chen, Cuiping Chen, Yangcan Ming, Jiahao Du, Jinyi Mu, Fang Luo, Da Huang,* Na Wang,* Zhenyu Lin and Zuquan Weng.* Colon-targeted oral nanoparticles based on ROS-scavenging hydroxyethyl starch-curcumin conjugates for efficient inflammatory bowel disease therapy. International Journal of Pharmaceutics 2022, 623, 121884. IF=6.51

8. Fang Luo, Yating Zhang, Yexin Zu, Shiqing Li, Yiting Chen, Zhonghui Chen, Da Huang,* Bin Qiu, Zhenyu Lin.* Quick preparation of water-soluble perovskite nanocomposite via cetyltrimethylammonium bromide and its application. Microchimica Acta 2022, 189, 68. IF=6.408

9. Da Huang, Kristoffer Valerie, Hu Yang.* Clickable biocompatible brush polymers as a versatile platform toward development of multifunctional drug delivery vehicles. Reactive and Functional Polymers 2022, 170, 105147. IF=4.966

10. Fang Luo, Shiqing Li, Limei Cui, Yexing Zu, Yiting Chen, Da Huang,* Zuquan Weng, Zhenyu Lin.* Biocompatible perovskite quantum dots with superior water resistance enable long-term monitoring of the H2S level in vivo. Nanoscale 2021, 13, 14297-14303. IF=8.307

11. Shuting Chen, Jie Wu, Qiang Tang, Chenlan Xu, Yan Huang, Da Huang,* Fang Luo, Yuanzi Wu, Fen Yan, Zuquan Weng* and Shaoyun Wang. Nano-micelles based on hydroxyethyl starch-curcumin conjugates for improved stability, antioxidant and anticancer activity of curcumin. Carbohydrate Polymers 2020, 228, 115398. IF=10.723

12. Jiamin Chen, Yi Lu, Fen Yan, Yuanzi Wu, Da Huang* and Zuquan Weng*. A fluorescent biosensor based on catalytic activity of platinum nanoparticles for freshness evaluation of aquatic products. Food Chemistry 2020, 310, 125922. IF=9.231

13. Da Huang, Mi Sun, Yazhong Bu, Fang Luo, Cuiying Lin,* Zhenyu Lin, Zuquan Weng, Fei Yang* and Decheng Wu. Microcapsule-embedded hydrogel patches for ultrasound responsive and enhanced transdermal delivery of diclofenac sodium. Journal of Materials Chemistry B 2019, 7, 2330-2337. IF=7.571

14. Lixu Wang, Chaoqun Chen, Huawei Huang, Da Huang,* Fang Luo, Bin Qiu, Longhua Guo,* Zhenyu Lin and Huanghao Yang. Sensitive detection of telomerase activity in cancer cells using portable pH meter as readout. Biosensors & Bioelectronics 2018, 121, 153-158. IF=12.545

15. Da Huang, Yaping Zhuang, Fei Yang, Hong Shen, Xing Wang and Decheng Wu.* Acetal-linked PEGylated paclitaxel prodrugs forming free-paclitaxel-loaded pH-responsive micelles with high drug loading capacity and improved drug delivery. Materials Science & Engineering: C 2018, 82, 60-68. IF=8.457

16. Da Huang and Decheng Wu.* Biodegradable dendrimers for drug delivery. Materials Science & Engineering: C 2018, 90, 713-727. IF=8.457

17. Da Huang, Yaqiang Wang, Fei Yang, Hong Shen, Zuquan Weng and Decheng Wu.* Charge-reversible and pH-responsive biodegradable micelles and vesicles from linear-dendritic supramolecular amphiphiles for anticancer drug delivery. Polymer Chemistry 2017, 8, 6675-6687. IF=5.364

18. Da Huang, Fei Yang, Xing Wang, Hong Shen, Yezi You and Decheng Wu.* Facile synthesis and self-assembly behavior of pH-responsive degradable polyacetal dendrimers. Polymer Chemistry 2016, 7, 6154-6158. IF=5.364

19. Da Huang, Dawei Li, Tiantian Wang, Hong Shen, Pei Zhao, Baoxia Liu, Yezi You, Yuanzheng Ma,* Fei Yang,* Decheng Wu* and Shenguo Wang. Isoniazid conjugated poly(lactide-co-glycolide): long-term controlled drug release and tissue regeneration for bone tuberculosis therapy. Biomaterials 2015, 52, 417-425. IF=15.304

获奖情况

2024.10指导学生获2024年研究生国家奖学金

2023.07获福州大学2023届优秀本科生毕业论文指导教师奖

2019.10指导学生获2019年研究生国家奖学金

其他

指导研究生多人赴中科院、厦门大学、华南理工大学等知名院校攻读博士,进一步深造。

Researchgate个人主页: https://www.researchgate.net/profile/Da-Huang-5