职称：教授，博士生导师

学历：博士研究生

电子邮件： shixa@fzu.edu.cn

一、研究方向：

1. 生物材料与组织工程

2. 合成生物技术与生物催化

3. 酶定向进化与改造

4. 海洋生物技术

二、博士生招生专业：

1. 生物医学工程（学术型）

2. 生物与医药（专业学位型）

三、硕士生招生专业：

1. 生物工程（学术型）

2. 生物医学工程（学术型）

3. 生物技术与工程（专业学位型）

教育工作经历：

1994.8至今：福州大学生物科学与工程学院，助教、讲师、副教授、教授

2015.1-2016.1：美国农业部东部研究中心（ERRC）访学

2002.9-2009.3，华南理工大学，生物化工，博士

1998.9-2001.3，福州大学，化学工程，硕士

1990.9-1994.7，华东理工大学，生物化工，本科

教学简介：

讲授本科生课程：《合成生物学》、《微生物遗传育种学》

讲授研究生课程：《生物催化与转化工程》、《生物催化原理与应用》

参编教材：《药物生物技术》（高等教育出版社）、《微生物工程》（科学出版社）

科研简介：

主持福建省科技重大专项（经费450万元）、国家海洋公益专项子任务（276万元）等国家级和省级纵向课题；作为第二负责人主持国家海洋公益专项（2351万元）；主持硫酸软骨素生产技术（423万元）及生物敷料生产技术（270万元）等横向课题。在Advanced Functional Materials（IF18.5/Q1）等期刊上发表研究论文150余篇，授权发明专利30余件，相关研究成果已在7家企业应用，获5项福建省科学技术奖。

社会兼职：

中国微生物学会会员、美国化学会（ACS）会员、美国癌症研究协会（AACR）会员、国际仿生工程学会会员、福建省生物工程学会常务理事、福建省生物医学工程学会常务理事、福建省肿瘤生物治疗重点实验室学术委员会委员、福建省产业计量技术委员会委员；

为Nano-Micro Letters（IF31.6）、Advanced Materials（IF27.4）、Advanced Functional Materials（IF18.5）等期刊审稿人。

科研项目：

主持经费超过100万元项目

1. 福建省科技重大专项“海洋生物资源高值化利用技术研究”（450万元）

2. 国家海洋公益专项子任务“β-葡萄糖苷酶分离提取和产业化工艺的关键技术应用性研究开发”（276万元）

3. 横向项目“海洋硫酸软骨素生产技术”（423万元）

4. 横向项目“用于皮肤修复的生物敷料生产技术”（270万元）

5. 横向项目“干细胞医疗器械关键技术研发”（100万元）

6. 国家海洋公益性行业科研专项“药源生物活性物质产业化应用关键技术研究和示范”（2351万元，第二负责人及后期实际负责人）。

代表性论文：（#为第一作者，*为通讯作者）

1. Y Lv, F Cai, X Zhao, X Zhu, F Wei, Y Zheng, X Shi*, J Yang*, Bioinspired microstructured Janus bioadhesive for the prevention of abdominal and intrauterine adhesions. Advanced Functional Materials 2024, 2314402

2. X Zhao, Y Zhuang, Y Cao, F Cai, Y Lv, Y Zheng, J Yang*, X Shi*, Electrospun biomimetic periosteum capable of controlled release of multiple agents for programmed promoting bone regeneration, Advanced Healthcare Materials 2024, 202303134.

3. Mingmao Chen, Yulei Fu, Yan Liu,* Baihe Zhang, Xiaorong Song, Xinchun Chen, Zhengjia Zhu, Hang Gao, Jianmin Yang, and Xianai Shi*, NIR-Light-Triggered Mild-Temperature Hyperthermia to Overcome the Cascade Cisplatin Resistance for Improved Resistant Tumor Therapy, Advanced Healthcare Materials 2024, 202303667.

4. J Yang, Y He, Z Li, X Yang, Y Gao, M Chen, Y Zheng, S Mao*, X Shi*, Intelligent wound dressing for simultaneous in situ detection and elimination of pathogenic bacteria. Acta Biomaterialia 2024, 174, 177–190.

5. Yicheng Lv, Liang Li, Jingyuan Zhang, Jingsi Li, Fengying Cai, Yufeng Huang, Xiaomeng Li, Yunquan Zheng, Xianai Shi,* and Jianmin Yang*, Visible-Light Cross-Linkable Multifunctional Hydrogels Loaded with Exosomes Facilitate Full-Thickness Skin Defect Wound Healing through Participating in the Entire Healing Process. ACS Applied Materials & Interfaces 2024, 16, 25923-25937.

6. Jianmin Yang*, Fengying Cai, Yicheng Lv, Ting Jiang, Xingkai Zhao, Xueli Hu, Yunquan Zheng, Xianai Shi,* Chitosan nonwoven fabric composited calcium alginate and adenosine diphosphate as a hemostatic bandage for acute bleeding wounds. International Journal of Biological Macromolecules 2024, 257, 128561.

7. Wenqiang Liao, Siqi Xiao, Jianmin Yang, Xianai Shi, Yunquan Zheng,* Multifunctional nanogel based on carboxymethyl cellulose interfering with cellular redox homeostasis enhances phycocyanobilin photodynamic therapy. Carbohydrate Polymers 2024, 323, 121416.

8. Li Zhao, Wenqiang Liao, Guibin Lin, Jianmin Yang, Xianai Shi, Yunquan Zheng,* Rubropunctatin-silver composite nanoliposomes for eradicating Helicobacter pylori in vitro and in vivo. International Journal of Pharmaceutics 2024, 649, 123655.

9. Yongjian Cao, Haijie Zhang, Mengjie Qiu, Yunquan Zheng,* Xianai Shi, Jianmin Yang,* Biomimetic injectable and bilayered hydrogel scaffold based on collagen and chondroitin sulfate for the repair of osteochondral defects. International Journal of Biological Macromolecules 2024, 257, 128593.

10. Mengjie Qiu, Yating He, Haijie Zhang, Yunquan Zheng,* Xianai Shi, Jianmin Yang, Platelet-Rich Plasma (PRP) Based on Simple and Efficient Integrated Preparation Precises Quantitatively for Skin Wound Repair. International Journal of Molecular Sciences 2024, 25, 9340.

11. Haijie Zhang, Yinbo Wu, Mengjie Qiu, Yunquan Zheng,* Li Chen, Xianai Shi, Jianmin Yang, Qiong Lin, Jianqing Lin,* Lotus leaf Nuciferine improves sleep and reduces the low neuronal activity and brain tissue abnormalities associated with insomnia. Food Bioscience 2024, 62, 105345.

12. Mingming Zhao, Jeongwon Kim, Jiayan Jiao, Yelin Lim, Xianai Shi, Shaobin Guo*, Jongmin Kim*, Construction of multilayered gene circuits using de-novo-designed synthetic transcriptional regulators in cell-free systems, Journal of Biological Engineering 2024, 18, 64.

13. Y Lv, F Cai, Y He, L Li, Y Huang, J Yang*, Y Zheng, X Shi*, Multi-crosslinked hydrogels with strong wet adhesion, self-healing, antibacterial property, reactive oxygen species scavenging activity, and on-demand removability for seawater-immersed wound healing, Acta Biomaterialia 2023, 159: 95−110.

14. Z Fang#, Y Lv#, H Zhang#, Y He, H Gao, C Chen, D Wang, P Chen, S Tang, J Li, Z Qiu, X Shi, L Chen*, J Yang*, X Chen*, A multifunctional hydrogel loaded with two nanoagents improves the pathological microenvironment associated with radiation combined with skin wounds, Acta Biomaterialia 2023, 159: 111−127.

15. W Wang, J Dai, Y Huang, X Li, J Yang*, Y Zheng, X Shi*, Extracellular matrix mimicking dynamic interpenetrating network hydrogel for skin tissue engineering, Chemical Engineering Journal 2023, 457: 141362.

16. F Cai#, Y Ren#, J Dai, J Yang*, X Shi*, Effects of various cell surface engineering reactions on the biological behavior of mammalian cells, Macromolecular Bioscience 2023, 23, 2200379.

17. J Li, X Sun, J Dai, J Yang*, Liang Li, Z Zhang, J Guo, S Bai*, Y Zheng, X Shi*, Biomimetic multifunctional hybrid sponge via enzymatic cross-linking to accelerate infected burn wound healing, International Journal of Biological Macromolecules 2023, 225, 90–102.

18. S Ning, C Wang, L Zhao, Y Huang, J Yang, X Shi, Y Zheng*, Lecithinitosan nanoparticle drug carrier improves anti-tumor efficacy of Monascus pigment rubropunctatin, International Journal of Biological Macromolecules 2023, 242: 125058.

19. S Xiao, Z Lu, J Yang, X Shi, Y Zheng*, Phycocyanobilin from Arthrospira platensis: A potential photodynamic anticancer agent, Dyes and Pigments 2023, 219: 111516.

20. C He, B Yu, Y Lv, Y Huang, J Guo, L Li, M Chen, Y Zheng, M Liu, S Guo*, X Shi, J Yang*, Biomimetic Asymmetric Composite Dressing by Electrospinning with Aligned Nanofibrous and Micropatterned Structures for Severe Burn Wound Healing, ACS Applied Materials & Interfaces 2022, 14, 29, 32799-32812.

21. Z Zhang, J Guo, Y He, J Han, M Chen, Y Zheng, S Zhang, S Guo*, X Shi, J Yang^⁎, An injectable double network hydrogel with hemostasis and antibacterial activity for promoting multidrug-resistant bacteria infected wound healing, Biomaterials Science 2022, 10, 3268−3281.

22. G Wang*, Z Jiang, Q Xiao, C Jiang, X Shi*,Visible spectrophotometric assay for characterization of ω-transaminases, Analytical Biochemistry 2022, 658:114933

23. S Li, X Zhong, Y Xu, Y Zheng*, X Shi, F Li, S Guo, J Yang*, Smartphone-based reading system integrated with phycocyanin-enhanced latex nanospheres immunoassay for on-site determination of aflatoxin B1 in foodstuffs, Food Chemistry 2021, 360, 130019.

24. J Yang, Yufeng Huang, Jiajia Dai, Xianai Shi, Yunquan Zheng*, A sandwich structure composite wound dressing with firmly anchored silver nanoparticles for severe burn wound healing in a porcine model, Regenerative Biomaterials 2021, 8, rbab037.

25. Li F*, Wang L, Luo Y, Shi X*. Safety assessment of desaminotyrosine: Acute, subchronic oral toxicity, and its effects on intestinal microbiota in rats. Toxicology and Applied Pharmacology 2021, 417: 115464.

26. Y Yang, Q Liu, X Shi, Q Zheng, L Chen*, Y Sun*, Advances in plant-derived natural products for antitumor immunotherapy, Archives of Pharmacal Research 2021, 44, 987–1011.

27. L Li, X Zhong, Y Zheng*, S Guo, X Shi*, J Huang, Enhancement of biomass production and productivity of Arthrospira platensis GMPA7 using response surface monitoring methodology and turbidostatic cultivation strategy, Journal of Applied Phycology 2021, 33: 755-763.

28. X Feng, X Zhang, S Li, Y Zheng^⁎, X Shi, F Li, S Guo, J Yang^⁎, Preparation of aminated fish scale collagen and oxidized sodium alginate hybrid hydrogel for enhanced full-thickness wound healing, International Journal of Biological Macromolecules 2020, 164, 626–637.

29. Bangrui Yu, Chenhui He, Weibin Wang, Yafeng Ren, Jianmin Yang,* Shaobin Guo, Yunquan Zheng, and Xianai Shi*. Asymmetric Wettable Composite Wound Dressing Prepared by Electrospinning with Bioinspired Micropatterning Enhances Diabetic Wound Healing, ACS Applied Bio Materials 2020, 3, 5383−5394

30. Jimin Sun, Yafeng Ren, Weibin Wang, Huili Hao, Mingyu Tang, Zibo Zhang, Jianmin Yang*, Yunquan Zheng, and XianAi Shi*, Transglutaminase-catalyzed encapsulation of individual mammalian cells with biocompatible and cytoprotective gelatin nanoshells, ACS Biomaterials Science and Engineering 2020, 6, 2336−2345

31. Li F*, Li Y, Li Q, Shi X*. Eriobotrya japonica leaf triterpenoid acids ameliorate metabolic syndrome in C57BL/6J mice fed with high-fat diet. Biomedicine & Pharmacotherapy 2020, 132: 110866.

32. 杨建民, 郝慧丽, 王伟彬, 石贤爱*, 单哺乳动物细胞封装技术研究进展, 中国科学: 生命科学2020, 50, 406−426. (综述)

33. Lingling Wu, Hongming Ding, Xin Qu, Xianai Shi, Jianmin Yang, Mengjiao Huang, Jialu Zhang, Huimin Zhang, Jia Song, Lin Zhu, Yanling Song*, Yuqiang Ma*, and Chaoyong Yang*. Fluidic multivalent membrane   nanointerface enables synergetic enrichment of circulating tumor cells with   high efficiency and viability, Journal of the American Chemical Society 2020, 142, 4800−4806.

34. Zeng Wei, Xianai Shi^#, Rong Lian,Weibin Wang, Wenrong Hong and Shaobin Guo. Exclusive Production of Gentamicin C1a from Micromonospora purpurea by Metabolic Engineering, Antibiotics 2019, 8, 267-275; doi:10.3390 /antibiotics 8040267

35. Hu Shengxue, Cai Xianqun, Qu Xin, Yu Bangrui, Yan Chenyan, Yang Jianmin, Li Feng, Zheng Yunquan, Shi Xianai^*. Preparation of biocompatible wound dressings with long-term antimicrobial activity through covalent bonding of antibiotic agents to natural polymers, International Journal of Biological Macromolecules 2018:1879-0003

36. Xianqun Cai, Shengxue Hu, Bangrui Yu, Yilei Cai, Jianmin Yang, Feng Li, Yunquan Zheng, Xianai Shi^*. Transglutaminase-catalyzed preparation of crosslinked carboxymethyl chitosan/carboxymethyl cellulose/collagen composite membrane for postsurgical peritoneal adhesion prevention, Carbohydrate Polymers 2018, 20:201-210. https://doi.org/10.1016/j.carbpol.2018.08.065

37. Yunquan Zheng, Liangbin Li, Xianai Shi*, Zhijian Huang, Feng Li, Jianmin Yang and Yanghao Guo. Nonionic surfactants and their effects on asymmetric reduction of 2-octanone with Saccharomyces cerevisiae. AMB Express 2018, 8:111-117. https://doi.org/10.1186/s13568-018-0640-1

38. Feng Li, Qingxian Li, Xianai Shi*, Yanghao Guo. Maslinic acid inhibits impairment of endothelial functions induced by high glucose in HAEC cells through improving insulin signaling and oxidative stress. Biomedicine & Pharmacotherapy 2017, 95:904-913. doi: 10.1016/j.biopha.2017.09.001

39. 石贤爱^#，林海虹，王晓萍，方世银. 醇脱氢酶同工酶基因表达与酿酒酵母催化2-辛酮不对称还原的关系. 过程工程学报 2017, 17(4):827-833

40. 陈荫楠，刘震，石贤爱*, 王祖鑫. 密码子优化提高多粘类芽孢杆菌β-葡萄糖苷酶异源表达量. 中国生物化学与分子生物学报 2017, 33(4):414-422

41. 李锋，方世银，石贤爱*. 有机介质处理酿酒酵母对其催化不对称还原反应性能的影响. 过程工程学报 2017, 17(6):1281-1286

42. 陈倩，陈荫楠，陈东海，林海虹，石贤爱*. 基于单链抗体的呋喃唑酮 酶联免疫检测方法的建立. 食品科学 2017, 38(20):242-247

43. 陈荫楠，陈华，石贤爱*，叶小军，樊海平. 抗呋喃唑酮单克隆抗体的制备及其应用. 食品科学 2016, 3:157-163

44. 何丽妃，薛原楷，石贤爱*. 特殊反应体系中交联β-葡萄糖苷酶聚集体催化合成红景天苷. 过程工程学报 2015, 2:313-317  

45. 刘震，陈倩，陈荫楠，王祖鑫，朱秋享，石贤爱*. 枯草芽孢杆菌β-糖苷酶的克隆表达、体外定向进化及结构模拟. 微生物学报 2015, 55(10):1273-1283

46. 石贤爱^#，裴世锋，李向楠，朱秋享，叶小军，樊海平. 基于不同半抗原的呋喃唑酮代谢物免疫检测方法的建立与比较. 食品科学 2014, 35(8):36-42

47. 吴星涛，薛原楷，石贤爱*. 磁性交联 β-葡萄糖苷酶聚集体的制备及性质. 生物物理学报 2013, 29(10):769-778

48. Xian-Ai Shi^#, Hang Wang, Hao Wang, Zhiming Wang, and Chun Meng. Transferring chromosome DNA fragments from multiple donor cells into a host strain for yeast strain improvement, Canadian Journal of Microbiology 2012, 58: 760–766

49. 岳磊，林琼妹，许格，林磊，石贤爱*. 含离子液体介质中酶催化糖基化合成4-羟基苯乙基β-D-葡萄糖苷. 分子催化 2011, 25(3):269-275

50. 杨锦，方世银，石贤爱*. 水相中酿酒酵母催化3-氯-1-苯丙酮的不对称还原反应. 过程工程学报 2011, 11(2):324-328

51. 石贤爱^#，李聪颖，傅娟，孟春，郭养浩，娄文勇，吴虹，宗敏华. 表面活性剂对面包酵母细胞催化2－辛酮不对称还原反应的影响. 过程工程学报2009, 10(2)339-343

52. Shi Xian-Ai^#, Zong, Min-Hua*, Lou Wen-Yong. Effect of ionic liquids on catalytic characteristics of horse liver alcohol dehydrogenase. Chinese Journal of Chemistry 2006, 24 (11): 1643-1647

53. 石贤爱^#，娄文勇，宗敏华，郭养浩，孟春. Candida rugosa脂肪酶催化(R,S)-2-辛醇酯交换反应的对映选择性.华南理工大学学报(自然科学版) 2006, 34(12):30-34

54. 石贤爱^#，宗敏华，孟春，郭养浩. 含离子液体BMIm•Cl反应介质中马肝醇脱氢酶的催化特性, 催化学报 2005, 26(11):982-986

获奖情况

获5项福建省科学技术奖和福州大学青年“五四”奖章。

其他

任福州大学生物科学与工程学院副院长（分管科研和研究生培养）、科技部健康医疗器械国际科技合作基地副主任、福建省医疗器械和生物医药重点实验室副主任、福建省海洋生物制品绿色制造工程研究中心副主任、福州市海洋生物制品行业创新中心主任、福州大学药物生物技术与工程研究所所长、福建省科技重大专项“海洋生物资源高值化利用技术研究”首席专家、福州市十四五生物医药战略性新兴产业集群建设方案撰写组组长。

课题组网站（石贤爱教授课题组）：https://www.x-mol.com/groups/xianai_shi