职称：教授,博士生导师

学历：博士研究生

电话：

电子邮件：xiuyunye@fzu.edu.cn

研究方向：蛋白质与酶工程、微生物资源的开发与利用、酶制剂及其它生物活性物质的分子生物学和基因工程改良、食品生物技术；

教育工作经历：

1979.09-1983.07 福州大学化学化工系；大学本科

1983.07-1986.05 福建省南靖合成氨厂；助理工程师

1986.05-1989.10 福建省化工设计院；助理工程师

1989.10-1992.03 日本国广岛大学应用生物学系；硕士研究生

1992.03-1995.03 日本国广岛大学应用生物学系；博士研究生

1995.03-1996.04 日本国农林水产省食品综合研究所；博士后

1996.04-1997.09 加拿大农业部列桥研究中心；博士后

1997.09-2002.05 香港中文大学医学院生物化学系；博士后、研究员.

2002.05-至今 福州大学生物科学与工程学院；特聘教授，教授

教学简介：

承担的《蛋白质化学》课程被评为福建省精品课程，获福建省教学成果二等奖4项。

科研简介：

长期从事基因工程在酶制剂工业中的应用研究与开发，在酶制剂及其它生物活性物质的分子生物学和基因工程改良、高效表达等方面积累了丰富的经验，并取得了丰硕的科研成果。对不同环境微生物的认识与利用，建立了产酶微生物资源库和微生物酶基因资源库；开发不同环境来源酶等新产物，重点开展酶制剂在海洋生物资源、寡糖生产、食品、生物医药开发中的应用，探讨生物催化的应用途径。

主持了国家海洋局海洋公益性行业科研专项、863子课题、国家自然科学基金、福建省发改委产业技术开发专项、福建省经贸委企业技术创新专项等10多项国家及省部级重大科研项目的研究工作。研究成果获得了国家技术发明奖二等奖，国家科技进步二等奖，中国轻工业联合会科学技术发明奖一等奖，省科技进步二、三等奖，省专利三等奖等多项奖励；授权国家发明专利18项，国际发明专利2项；在国际性影响因子较高的专业学术刊物上先后发表了学术论文100多篇，其中被SCI收录的论文达80多篇；参与出版专著2部，教材2部。

社会兼职：

1、 酶高效表达国家工程实验室主任；

2、 福建省海洋酶工程重点实验室主任；

3、 福建省食品生物技术开发基地主任；

4、 农工党福建省省委常委，农工党福州大学主委；

5、 福建省食品科学技术学会副理事长，福建省食品安全专家，福建省保健食品安全专家；

科研项目：

1、国家海洋局“海洋酶工程创新服务平台”（2017-2020）

2、国家海洋局海洋公益性行业科研专项“几种海洋生物酶及系列功能产品研发与应用示范”（2013-2016）；

3、国家科技部863子课题“新型糖酶创制与创新应用关键技术研究”（2013-2017）；

4、福建省海洋高新产业发展专项“海洋生物酶研发及产业化平台建设”（2013-2016）；

5、福建省经贸委“功能食品研究与开发共享平台的建设”（2012-2014）；

6、福建省经贸委“食品微生物菌种资源共享平台的建设”（2010-2012）；

7、 福建省经贸委“食品酶工程应用技术服务平台建设”（2009-2011）；

8、福建省发改委产业技术开发专项“转基因鹿茸促成骨细胞生长因子的高效表达及工业化生产技术”（2009-2011）；

9、国家自然科学基金项目“鹿茸促成骨细胞生长协同作用组分的分离鉴定及其分子作用机理研究”（2007-2009）.

代表性论文：

1.Xu X.Q., Su B.M., Xie J.S., Li R.K., Yang J., Lin J.and Ye X.Y. (2018). Preparation of bioactive neoagaroligosaccharides through hydrolysis of Gracilaria lemaneiformis agar: A comparative study. Food Chemistry,

2. Wang G., Wu J., Yan R., Lin J.andYe X.Y. (2017).A Novel Multi-domain High Molecular, Salt-Stable Alkaline Xylanase from Alkalibacterium sp. SL3. Front Microbiol 7: 2120.

3. Yang, J., Lin, Y., Yang, X., Ng, T. B., Ye, X.Y.and Lin, J (2017). Degradation of tetracycline by immobilized laccase and the proposed transformation pathway. Journal of Hazardous Materials, 322, 525-531.

4. Wang G., Wang Q., Lin X., Ng T.B., Yan R., Lin J.andYe X.Y.(2016). A novel cold-adapted and highly salt-tolerant esterase from Alkalibacterium sp. SL3 from the sediment of a soda lake. Sci Rep 6: 19494.

5. Yang J., Xu, X., Yang, X., Ye, X.Y and Lin, J (2016). Cross-linked enzyme aggregates of Cerrena laccase: preparation, enhanced NaCl tolerance and decolorization of Remazol Brilliant Blue Reactive. Journal of the Taiwan Institute of Chemical Engineers, 65, 1-7.

6. Yang J., Yang X., Ye X.Y. and Lin, J. (2016). Optimal parameters for laccase-mediated destaining of Coomassie Brilliant Blue R-250-stained polyacrylamide gels. Data in Brief, 7, 1-7.

7. Yang, J., Yang, X., Ye, X.Y. and Lin, J. (2016). Destaining of Coomassie Brilliant Blue R-250-stained polyacrylamide gels with fungal laccase. Analytical Biochemistry, 493, 27-29.

8. Yang, J., Wang, G., Ng, T. B., Lin, J., and Ye, X.Y. (2016). Laccase production and differential transcription of laccase genes in Cerrena sp. in response to metal ions, aromatic compounds, and nutrients. Frontiers in Microbiology, 6, 1558.

9. Ng T.B., Cheung R.C., Wong J.H., Chan Y.S., Dan X., Pan W., Wang H., Guan S, Chan K, Ye X.Y., Liu F, Xia L, Chan WY (2016). Fungal proteinaceous compounds with multiple biological activities, Appl Microbiol Biotechnol., 100(15):6601-17.

10. Yang J., Xu, X., Ng, T. B., Lin, J., and Ye, X.Y.(2016). Laccase gene family in Cerrena sp. HYB07: sequences, heterologous expression and transcriptional analysis. Molecules, 21, 1017.

11. Li R.K., Chen P., Ng T.B., Yang J., Lin J., Yan F., and Ye X.Y.(2015). Highly efficient expression and characterization of a β-mannanase from Bacillus subtilis in Pichia pastoris.Biotechnol Appl Biochem. 62(1):64-70

12. Wang G., Wu J., Lin J., Ye X.Y. and Yao B. (2016). The disruption of two salt bridges of the cold-active xylanase XynGR40 results in an increase in activity, but a decrease in thermostability. Biochem Biophys Res Commun 481: 139-145.

13. Yang, J., Yang, X., Lin, Y., Ng, T. B., Lin, J. and Ye, X.Y. (2015) Laccase-catalyzed decolorization of malachite green: Performance optimization and degradation mechanism. PLoS ONE, 10, e0127714

14. Huang X., Lin J., Ye X.Y.and Wang G. (2015). Molecular Characterization of a Thermophilic and Salt- and Alkaline-Tolerant Xylanase from Planococcus sp. SL4, a Strain Isolated from the Sediment of a Soda Lake. J Microbiol Biotechnol 25: 662-671.

15. Yang, J., Lin, Q., Lin, J., and Ye, X.Y. (2016). Selection and validation of reference genes for quantitative real-time polymerase chain reaction studies in Cerrena unicolor (higher basidiomyetes). International Journal of Medicinal Mushrooms, 18, 165-175.

16 Yang, J., Ng, T. B., Lin, J. and Ye, X.Y. (2015).A novel laccase from basidiomycete Cerrena sp.: Cloning, heterologous expression, and characterization. International Journal of Biological Macromolecules, 77, 344-349.

17. Yang, J., Lin, Q., Ng, T. B., Ye, X.Y. and Lin, J (2014).Purification and characterization of a novel laccase from Cerrena sp. HYB07 with dye decolorizing ability. PLoS ONE, 9, e110834.

18. Wang G., Huang X., Ng T.B., Lin J.andYe X.Y.(2014).High phylogenetic diversity of glycosyl hydrolase family 10 and 11 xylanases in the sediment of Lake Dabusu in China.PLoS One 9: e112798.

19. Li R.K., Fu C.L., Chen P., Ng T.B. and Ye X.Y. (2013). High-level expression of a sika deer (Cervus nippon) Cu/Zn superoxide dismutase in Pichia pastoris and its characterization. Environ Toxicol Pharmacol. 35(2):185-92.

20. Wang S.Y., Ye X.Y. and Rao P.F. (2012). Isolation of a novel leguminous lysozyme and study on the antifungal activity.Food research international, 47(2):341-347

21. Wang S.Y., Shao B., Liu S.T., Ye X.Y. and Rao P.F. (2012). Purification and characterization of Cu, Zn-superoxide dismutase from black soybean.Food research international, 47(2):374-379

22. Wang S.Y., Ye X.Y., Chen J. and Rao P.F. (2012). A novel chitinase isolated from Vicia faba and its antifungal activity. Food research international, 45(1):116-122

23.Ng T.B., Wong J.H, Fang EF, Chan YS, Pan W, Ye X.Y., Sze SC, Zhang KY, Liu F, Wang HX (2011) Glyceollin, a soybean phytoalexin with medicinal properties. Appl Microbiol Biotechnol.90(1):59-68.

24. Shaoyun Wang S. Y,. Biao Shao B., Liu S T., Ye X.Y., Pingfan Rao (2011) Purification and characterization of Cu, Zn-superoxide dismutase from black soybean.Food Research International.

25. Ng T. B.，Jack Ho Wong，Evandro Fei Fang，Yau Sang Chan，Wenliang Pan，Xiu Yun Ye，Stephen Cho Wing Sze，Kalin Yanbo Zhang，Fang Liu，He Xiang Wang.Glyceollin, a soybean phytoalexin with medicinal properties. Applied Microbiology and Biotechnology. 2011.Apr;90(1):59-68. Epub 2011 Feb 20

26. Jack H. Wong，T. B. Ng，Randy C. F. Cheung，X. J. Ye，H. X. Wang，S. K. Lam，P. Lin，Y. S. Chan，Evandro F. Fang，Patrick H. K. Ngai，L. X. Xia，X. Y. Ye，Y. Jiang，F. Liu.2010. Proteins with antifungal properties and other medicinal applications from plants and mushrooms. Appl Microbiol Biotechnol. Jul;87(4):1221-35

27. Shaoyun Wang¹, Pingfan Rao¹ and Xiuyun Ye¹ .Isolation and biochemical characterization of a novel leguminous defense peptide with antifungal and antiproliferative potency.Appl Microbiol Biotechnol. 2009 Feb;82(1):79-86.

28. Shaoyun Wang¹, Pingfan Rao¹ and Xiuyun Ye¹ .Isolation and biochemical characterization of a novel leguminous defense peptide with antifungal and antiproliferative potency.Appl Microbiol Biotechnol. 2009 Feb;82(1):79-86.

29. Wang S, Shao B, Rao P, Lee Y, Ye X.Y. Hypotin, a novel antipathogenic and antiproliferative protein from peanuts with a sequence similar to those of chitinase precursors.  J Agric Food Chem. 2007 Nov 28;55(24):9792-9. Epub 2007 Nov 3.

PMID: 17979231 [PubMed - indexed for MEDLINE]

30. Lin P, Xia L, Wong JH, Ng TB, Ye X.Y, Wang S, Shi X. Lipid transfer proteins from Brassica campestris and mung bean surpass mung bean chitinase in exploitability. J Pept Sci. 2007 Oct;13(10):642-8.

31.Wang S, Lin J, Ye M, Ng TB, Rao P, Ye XY. Isolation and characterization of a novel mung bean protease inhibitor with antipathogenic and anti-proliferative activities.Peptides. 2006 ec;27(12):3129-36.

32. Wang SY，Xu Z B，Ye XY, Rao P F. 2005. Purification and characterization of a malate dehydrogenase from Phaseolus mungo. Journal of food biochemistry, 29(2): 117-131.

33. Lin DY, Huang XN, Ke LJ, Chen XC, Ye XY, Huo YS, Rao PF, 2005. Purification and characterization of the proliferation of rat osteoblast-like cells UMR-106 from pilose antler. Zhongguo Zhong Yao Za Zhi. Jun;30(11):851-5

34. Wang SY, Wu J, Rao PF, Ng TB, Ye XY. 2005. A chitinase with antifungal activity from the mung bean.Protein Expr. Purif. Apr;40(2):230-6.

35. Wang SY, Ng TB, Chen T. Lin D, Wu J. Rao PF, Ye XY. 2005. First report of a novel plant lysozyme with both antifungal and antibacterial activities. Biochem. Biophys. Res. Commun. Feb 18;327(3):820-7.

36. Wang SY, Zhou KJ, Ye XY, Xu ZB, Wu JH, Rao PF. 2004. Crystallization and preliminary X-ray crystallographic analysis of a non-specific lipid-transfer protein with antipathogenic activity from Phaseolus mungo.Acta Crystallogr D Biol Crystallogr. Dec;60(Pt 12 Pt 2):2391-3. Epub 2004 Nov

37. Wang SY, Wu JH, Ng TB, Ye XY and Rao PF. 2004.A non-specific lipid transfer protein with antifungal and antibacterial activities from the mung bean. Peptides. 2004 Aug;25(8):1235-42.

38. Ng TB and Ye X.Y.2004. A polymeric immunoglobulin receptor-like milk protein with inhibitory activity on human immunodeficiency virus type 1 reverse transcriptase. Int J Biochem Cell Biol. 2004 Nov;36(11):2242-9.

39. Ng TB and Ye X.Y.2003. Fabin, a novel calcyon-like and glucanase-like protein with mitogenic, antifungal and translation-inhibitory activities from broad beans. Biol Chem. 2003 May;384(5):811-5.

40. Ye, X. Y. and Ng, T. B.2003.Purification and characterization of a new ribonuclease from fruiting bodies of the oyster mushroom Pleurotus ostreatus. J Pept Sci. 2003 Feb;9(2):120-4.

41. Ye, X. Y. and Ng, T. B.2003.Isolation of vulgin, a new antifungal polypeptide with mitogenic activity from the pinto bean. J Pept Sci. 2003 Feb;9(2):114-9.

42. Ye, X. Y. and Ng, T. B.2003.Isolation of pisumin, a novel antifungal protein from legumes of the sugar snap pea Pisum sativum var macrocarpon. Comp Biochem Physiol C Toxicol Pharmacol. 2003 Feb;134(2):235-40.

43. Ye, X. Y. and Ng, T. B.2002.A new peptidic protease inhibitor from Vicia faba seeds exhibits antifungal, HIV-1 reverse transcriptase inhibiting and mitogenic activities. J Pept Sci. 2002 Dec;8(12):656-62.

44. Ye, X. Y. and Ng, T. B.2002. Isolation of a novel peroxidase from French bean legumes and first demonstration of antifungal activity of a non-milk peroxidase. Life Sci. Aug 23;71(14):1667-1680.

45. Ye, X. Y. and Ng, T. B.2002. A new antifungal peptide from rice beans.J. Pept. Res. Aug;60(2):81-7.

46. Ye, X. Y. and Ng, T. B.2002. A novel peptide with ribonuclease and translation-inhibitory activities from fruiting bodies of the oyster mushroom Pleurotus ostreatus. J. Pept. Sci. Jun;8(6):235-40.

47. Ye, X. Y. and Ng, T. B.2002. Cicerin and arietin, novel chickpea peptides with different antifungal potencies. Peptides. May;23(5):817-22.

48. Ye, X. Y. and Ng, T. B.2002. A novel and potent ribonuclease from fruiting bodies of the mushroom Pleurotus pulmonarius. Biochem. Biophys. Res. Commun. May 3;293(2):857-61.

49. Ye, X. Y. and Ng, T. B.2002. Purification of angularin, a novel antifungal peptide from adzuki beans. J. Pept. Sci. Mar;8(3):101-6.

50. Ye, X. Y. and Ng, T. B.2002. Delandin, a Chitinase-like Protein with Antifungal, HIV-1 Reverse Transcriptase Inhibitory and Mitogenic Activities from the Rice Bean Delandia umbellata. Protein Expr Purif. Apr;24(3):524-9.

51. Ng, T. B., Lam, T. L., Au, T. K., Ye, X. Y. and Wan, C. C. 2002. Inhibitory effects of antifungal proteins on human immunodeficiency virus type 1 reverse transcriptase, protease and integrase. Life Sci.  Jan 11;70(8):927-35.

52. Ye, X. Y. and Ng, T. B.2002. Isolation of a new cyclophilin-like protein from chickpeas with mitogenic, antifungal and anti-HIV-1 reverse transcriptase activities. Life Sci. Jan 25;70(10):1129-38.

53. Ye, X. Y. and Ng, T. B.2002. A new antifungal protein and a chitinase with prominent macrophage-stimulating activity from seeds of Phaseolus vulgaris cv. pinto. Biochem. Biophys. Res. Commun. Jan 18;290(2):813-9.

获奖情况：

教学：获福建省教学成果二等奖4项。

科研：获国家技术发明奖二等奖，国家科技进步二等奖，中国轻工业联合会科学技术发明奖一等奖，省科技进步二、三等奖，省专利三等奖等多项奖励。

新世纪百千万人才工程省级人选。

其他